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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Evaluation of current rapid HIV test algorithms in Rakai, Uganda
Journal of Virological Methods, Volume 192, No. 1-2, Year 2013
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Description
Rapid HIV tests are a crucial component of HIV diagnosis in resource limited settings. In Uganda, the Ministry of Health allows both serial and parallel HIV rapid testing using Determine, Stat-Pak and Uni-Gold. In serial testing, a non-reactive result on Determine ends testing. The performance of serial and parallel algorithms with Determine and Stat-Pak test kits was assessed. A cross-sectional diagnostic test accuracy evaluation using three rapid HIV test kits as per the recommended parallel test algorithm was followed by EIA-WB testing with estimates of the performance of serial testing algorithm. In 2520 participants tested by parallel rapid algorithms, 0.6% had weakly reactive result. Parallel testing had 99.7% sensitivity and 99.8% specificity. If Stat-Pak was used as the first screening test for a serial algorithm, the sensitivity was 99.6% and specificity was 99.7%. However, if Determine was used as the screening test, sensitivity was 97.3% and specificity was 99.9%. Serial testing with Stat-Pak as the initial screening test performed as well as parallel testing, but Determine was a less sensitive screen. Serial testing could be cost saving. © 2013 Elsevier B.V.
Authors & Co-Authors
Galiwango, Ronald Moses
Uganda, Kalisizo
Rakai Health Sciences Program
Musoke, Richard M.
Uganda, Kalisizo
Rakai Health Sciences Program
Lubyayi, Lawrence
Uganda, Kalisizo
Rakai Health Sciences Program
Ssekubugu, Robert
Uganda, Kalisizo
Rakai Health Sciences Program
Kalibbala, Sarah N.
Uganda, Kalisizo
Rakai Health Sciences Program
Ssekweyama, Viola
Uganda, Kalisizo
Rakai Health Sciences Program
Mirembe, Viola
Uganda, Kalisizo
Rakai Health Sciences Program
Nakigozi, Gertrude F.
Uganda, Kalisizo
Rakai Health Sciences Program
Reynolds, Steven James
Uganda, Kalisizo
Rakai Health Sciences Program
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
United States, Baltimore
Johns Hopkins University
Serwadda, David Musoke
Uganda, Kalisizo
Rakai Health Sciences Program
Uganda, Kampala
Makerere University College of Health Sciences
Gray, Ronald H.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Kigozi, Godfrey G.
Uganda, Kalisizo
Rakai Health Sciences Program
Statistics
Citations: 67
Authors: 12
Affiliations: 5
Identifiers
Doi:
10.1016/j.jviromet.2013.04.003
ISSN:
01660934
e-ISSN:
18790984
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Uganda