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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Fumonisin B
1
and risk of hepatocellular carcinoma in two Chinese cohorts
Food and Chemical Toxicology, Volume 50, No. 3-4, Year 2012
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Description
Fumonisin B 1 (FB 1), a mycotoxin that contaminates corn in certain climates, has been demonstrated to cause hepatocellular cancer (HCC) in animal models. Whether a relationship between FB 1 and HCC exists in humans is not known. To examine the hypothesis, we conducted case-control studies nested within two large cohorts in China; the Haimen City Cohort and the General Population Study of the Nutritional Intervention Trials cohort in Linxian. In the Haimen City Cohort, nail FB 1 levels were determined in 271 HCC cases and 280 controls. In the General Population Nutritional Intervention Trial, nail FB 1 levels were determined in 72 HCC cases and 147 controls. In each population, odds ratios and 95% confidence intervals (95%CI) from logistic regression models estimated the association between measurable FB 1 and HCC, adjusting for hepatitis B virus infection and other factors. A meta-analysis that included both populations was also conducted. The analysis revealed no statistically significant association between FB 1 and HCC in either Haimen City (OR=1.10, 95%CI=0.64-1.89) or in Linxian (OR=1.47, 95%CI=0.70-3.07). Similarly, the pooled meta-analysis showed no statistically significant association between FB 1 exposure and HCC (OR=1.22, 95%CI=0.79-1.89). These findings, although somewhat preliminary, do not support an associated between FB 1 and HCC. © 2011.
Authors & Co-Authors
Christina Persson, E.
Unknown Affiliation
Sewram, Vikash
Unknown Affiliation
Evans, Alison A.
Unknown Affiliation
Thomas London, W.
Unknown Affiliation
Volkwyn, Yvette
Unknown Affiliation
Shen, Yen Ju
Unknown Affiliation
van Zyl, J.
Unknown Affiliation
Chen, Gang
Unknown Affiliation
Lin, Wen Yao
Unknown Affiliation
Shephard, Gordon Seymour
Unknown Affiliation
Taylor, Philip R.
Unknown Affiliation
Fan, Jinhu
Unknown Affiliation
Dawsey, Sanford M.
Unknown Affiliation
Qiao, Youlin
Unknown Affiliation
McGlynn, Katherine A.
Unknown Affiliation
Abnet, Christian C.
Unknown Affiliation
Statistics
Citations: 23
Authors: 16
Affiliations: 8
Identifiers
Doi:
10.1016/j.fct.2011.11.029
ISSN:
02786915
e-ISSN:
18736351
Research Areas
Cancer
Infectious Diseases
Study Design
Randomised Control Trial
Cross Sectional Study
Cohort Study
Case-Control Study
Study Approach
Systematic review