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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Umbilical vein oxytocin for the treatment of retained placenta (Release Study): a double-blind, randomised controlled trial
The Lancet, Volume 375, No. 9709, Year 2010
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Description
Background: Retained placenta is associated with post-partum haemorrhage. Meta-analysis has suggested that umbilical injection of oxytocin could increase placental expulsion without the need for a surgeon or anaesthetic. We assessed the effect of high-dose umbilical vein oxytocin as a treatment for retained placenta. Methods: In this double-blind, placebo-controlled trial, haemodynamically stable women with a retained placenta for more than 30 min were recruited from 13 sites in the UK, Uganda, and Pakistan. 577 women were randomly assigned by a computer-generated randomisation list stratified by centre to 30 mL saline containing either 50 IU oxytocin (n=292) or 5 mL water (n=285), which was injected into the placenta through an umbilical vein catheter. All trial participants, study workers, and data handlers were masked to individual allocations. The primary outcome was the need for manual removal of the placenta. Analysis was by intention to treat. This study is registered, number ISRCTN 13204258. Findings: The primary outcome was recorded for all participants. We detected no difference between the groups in the need for manual removal of placenta (oxytocin 179/292 [61·3%] vs placebo 177/285 [62·1%]; relative risk 0·98, 95% CI 0·87-1·12; p=0·84). The need for manual removal was higher in the UK (overall 250/361 [69%]) than in Uganda (90/190 [47%]) or Pakistan (16/26 [62%]). Adverse events did not differ between the two groups. Interpretation: Umbilical oxytocin has no clinically significant effect on the need for manual removal for women with retained placenta. Funding: WHO, WellBeing of Women, Pakistan Higher Education Commission. © 2010 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Weeks, Andrew D.
United Kingdom, Liverpool
University of Liverpool
Alia, Godfrey
Uganda, Kampala
Makerere University
Vernon, Gillian
United Kingdom, Liverpool
University of Liverpool
Namayanja, Annette
Uganda, Kampala
Makerere University
Gosakan, Radhika
United Kingdom, Sheffield
Jessop Wing
Majeed, Tayyaba
Pakistan, Lahore
Lady Willingdon Hospital
Hart, Anna
United Kingdom, Preston
University of Central Lancashire
Jafri, Hussain S.
Pakistan, Lahore
Lady Willingdon Hospital
Nardín, Juan Manuel
Argentina, Rosario
Centro Rosarino de Estudios Perinatales
Carroli, Guillermo
Argentina, Rosario
Centro Rosarino de Estudios Perinatales
Fairlie, Fiona
United Kingdom, Sheffield
Jessop Wing
Raashid, Yasmin
Pakistan, Lahore
Lady Willingdon Hospital
Mirembe, Florence Maureen
Uganda, Kampala
Makerere University
Alfirevic, Zarko
United Kingdom, Liverpool
University of Liverpool
Statistics
Citations: 44
Authors: 14
Affiliations: 6
Identifiers
Doi:
10.1016/S0140-6736(09)61752-9
ISSN:
01406736
Research Areas
Disability
Environmental
Study Design
Randomised Control Trial
Study Approach
Systematic review
Study Locations
Uganda
Participants Gender
Female