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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Assessment and comparative analysis of a rapid diagnostic test (Tubex
®
) for the diagnosis of typhoid fever among hospitalized children in rural Tanzania
BMC Infectious Diseases, Volume 11, Article 147, Year 2011
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Description
Background: Typhoid fever remains a significant health problem in many developing countries. A rapid test with a performance comparable to that of blood culture would be highly useful. A rapid diagnostic test for typhoid fever, Tubex®, is commercially available that uses particle separation to detect immunoglobulin M directed towards Salmonella Typhi O9 lipopolysaccharide in sera.Methods: We assessed the sensitivity and specificity of the Tubex test among Tanzanian children hospitalized with febrile illness using blood culture as gold standard. Evaluation was done considering blood culture confirmed S. Typhi with non-typhi salmonella (NTS) and non - salmonella isolates as controls as well as with non-salmonella isolates only.Results: Of 139 samples tested with Tubex, 33 were positive for S. Typhi in blood culture, 49 were culture-confirmed NTS infections, and 57 were other non-salmonella infections. Thirteen hemolyzed samples were excluded. Using all non - S. Typhi isolates as controls, we showed a sensitivity of 79% and a specificity of 89%. When the analysis was repeated excluding NTS from the pool of controls we showed a sensitivity of 79% and a specificity of 97%. There was no significant difference in the test performance using the two different control groups (p > 0.05).Conclusion: This first evaluation of the Tubex test in an African setting showed a similar performance to those seen in some Asian settings. Comparison with the earlier results of a Widal test using the same samples showed no significant difference (p > 0.05) for any of the performance indicators, irrespective of the applied control group. © 2011 Ley et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Ley, Benedikt B.
South Korea, Seoul
International Vaccine Institute, Seoul
Austria, Vienna
Universität Wien
Thriemer, Kamala L.
South Korea, Seoul
International Vaccine Institute, Seoul
Ame, Shaali Makame
Tanzania
Public Health Laboratory Pemba - Ivo de Carneri
Mtove, George A.
Tanzania, Tanga
National Institute for Medical Research Tanga
Tanzania, Tanga
Joint Malaria Programme
Von-Seidlein, Lorenz
South Korea, Seoul
International Vaccine Institute, Seoul
Tanzania, Tanga
Joint Malaria Programme
Australia, Darwin
Menzies School of Health Research
Amos, Ben
Tanzania, Tanga
Joint Malaria Programme
Tanzania, Tanga
Teule Hospital
Hendriksen, Ilse C.E.
Tanzania, Tanga
Joint Malaria Programme
Thailand, Nakhon Pathom
Mahidol University
Mwambuli, Abraham
Tanzania, Tanga
Joint Malaria Programme
Shoo, Aikande
Tanzania, Tanga
Joint Malaria Programme
Tanzania, Tanga
Teule Hospital
Kim, Deokryun
South Korea, Seoul
International Vaccine Institute, Seoul
Ochiai, R. Leon
South Korea, Seoul
International Vaccine Institute, Seoul
Favorov, Michael O.
South Korea, Seoul
International Vaccine Institute, Seoul
Clemens, John David
South Korea, Seoul
International Vaccine Institute, Seoul
Wilfing, Harald
Austria, Vienna
Universität Wien
Deen, Jacqueline L.
South Korea, Seoul
International Vaccine Institute, Seoul
Tanzania, Tanga
Joint Malaria Programme
Ali, Said Mohammed
Tanzania
Public Health Laboratory Pemba - Ivo de Carneri
Statistics
Citations: 44
Authors: 16
Affiliations: 8
Identifiers
Doi:
10.1186/1471-2334-11-147
e-ISSN:
14712334
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Randomised Control Trial
Study Locations
Tanzania