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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Macrophage- but not monocyte-derived extracellular vesicles induce placental pro-inflammatory responses
Placenta, Volume 69, Year 2018
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Description
The placenta sheds extracellular vesicles (EVs), including exosomes, into the maternal circulation. We recently demonstrated that this trafficking of EVs is bi‐directional; with uptake of macrophage exosomes by the placenta inducing cytokine release. The specificity of this response is currently unknown. THP-1 cells were cultured as monocytes or differentiated to macrophages, and EVs isolated by ultra-centrifugation. The effect of EVs on human placental explants was measured by cytokine ELISA/luminex. Macrophage, but not monocyte, EVs induce the release of pro-inflammatory cytokines by the placenta. Thus, placental responses to immune cell EVs, including exosomes, reflects the phenotype of the source cell. © 2018 Elsevier Ltd
Authors & Co-Authors
Rice, Thomas F.
United Kingdom, London
Imperial College London
Donaldson, Beverly
United Kingdom, London
Imperial College London
Bouqueau, Marielle
United Kingdom, London
Imperial College London
Kampmann, Beate B.
United Kingdom, London
Imperial College London
United Kingdom, London
London School of Hygiene & Tropical Medicine
Holder, Beth
United Kingdom, London
Imperial College London
United Kingdom, London
London School of Hygiene & Tropical Medicine
Statistics
Citations: 21
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1016/j.placenta.2018.07.011
ISSN:
01434004
Research Areas
Maternal And Child Health