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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Thermal ablation of liver metastases from colorectal cancer: Radiofrequency, microwave and laser ablation therapies
Radiologia Medica, Volume 119, No. 7, Year 2014
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Description
Surgery is currently considered the treatment of choice for patients with colorectal cancer liver metastases (CRLM) when resectable. The majority of these patients can also benefit from systemic chemotherapy. Recently, local or regional therapies such as thermal ablations have been used with acceptable outcomes. We searched the medical literature to identify studies and reviews relevant to radiofrequency (RF) ablation, microwave (MW) ablation and laser-induced thermotherapy (LITT) in terms of local progression, survival indexes and major complications in patients with CRLM. Reviewed literature showed a local progression rate between 2.8 and 29.7 % of RF-ablated liver lesions at 12-49 months follow-up, 2.7-12.5 % of MW ablated lesions at 5-19 months follow-up and 5.2 % of lesions treated with LITT at 6-month follow-up. Major complications were observed in 4-33 % of patients treated with RF ablation, 0-19 % of patients treated with MW ablation and 0.1-3.5 % of lesions treated with LITT. Although not significantly different, the mean of 1-, 3- and 5-year survival rates for RF-, MW- and laser ablated lesions was (92.6, 44.7, 31.1 %), (79, 38.6, 21 %) and (94.2, 61.5, 29.2 %), respectively. The median survival in these methods was 33.2, 29.5 and 33.7 months, respectively. Thermal ablation may be an appropriate alternative in patients with CRLM who have inoperable liver lesions or have operable lesions as an adjunct to resection. However, further competitive evaluation should clarify the efficacy and priority of these therapies in patients with colorectal cancer liver metastases. © 2014 Italian Society of Medical Radiology.
Authors & Co-Authors
Vogl, Thomas Josef
Germany, Frankfurt am Main
Universitätsklinikum Frankfurt
Farshid, Parviz
Germany, Osnabruck
Marienhospital Osnabrück
Naguib, Nagy Naeem
Germany, Frankfurt am Main
Universitätsklinikum Frankfurt
Egypt, Alexandria
Faculty of Medicine
Darvishi, Abbas
Germany, Frankfurt am Main
Universitätsklinikum Frankfurt
Bazrafshan, Babak
Germany, Frankfurt am Main
Universitätsklinikum Frankfurt
Mbalisike, Emmanuel C.
Germany, Frankfurt am Main
Universitätsklinikum Frankfurt
Burkhard, Thorsten
Germany, Frankfurt am Main
Universitätsklinikum Frankfurt
Zangos, Stephan
Germany, Frankfurt am Main
Universitätsklinikum Frankfurt
Statistics
Citations: 83
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1007/s11547-014-0415-y
ISSN:
00338362
Research Areas
Cancer
Health System And Policy
Study Design
Cohort Study