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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Ketosis-prone type 2 diabetes mellitus and human herpesvirus 8 infection in sub-Saharan Africans
JAMA, Volume 299, No. 23, Year 2008
Notification
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Description
Context: An atypical form of type 2 diabetes mellitus (DM-2) is revealed by ketosis (ketosis-prone type 2 diabetes mellitus), frequently occurring in individuals who are black and of African origin, and characterized by an acute onset requiring transient insulin therapy. Its sudden onset suggests precipitating factors. Objective: To investigate the putative role of human herpesvirus 8 (HHV-8) in the pathogenesis of ketosis-prone DM-2. Design, Setting, and Participants: A cross-sectional study in which antibodies were searched against latent and lytic HHV-8 antigens using immunofluorescence. The presence of HHV-8 in genomic DNA was investigated in 22 of the participants at clinical onset of diabetes. We also tested whether HHV-8 was able to infect human pancreatic β cells in culture in vitro. The study was conducted at Saint-Louis University Hospital, Paris, France, from January 2004 to July 2005. All participants were black and of African origin: 187 were consecutive diabetic patients of whom 81 had ketosis-prone DM-2 and 106 had nonketotic DM-2, and 90 individuals were nondiabetic control participants who were matched for age and sex. Main Outcome Measures: Seroprevalence of HHV-8 and percentage of patients with HHV-8 viremia at onset in ketosis-prone DM-2. Results: HHV-8 antibodies were found in 71 patients (87.7%) with ketosis-prone DM-2 vs 16 patients (15.1%) with nonketotic DM-2 (odds ratio, 39.9; 95% confidence interval, 17.1-93.4; P < .001) and 36 of the control participants (40.0%) (odds ratio, 10.7; 95% confidence interval, 4.9-23.4; P < .001). HHV-8 in genomic DNA was present in 6 of 13 patients with ketosis-prone DM-2 tested at acute onset and in 0 of 9 patients with nonketotic DM-2. HHV-8 proteins were present in human islet cells that were cultured for 4 days in the presence of HHV-8. Conclusions: In this preliminary cross-sectional study, the presence of HHV-8 antibodies was associated with ketosis-prone DM-2 in patients of sub-Saharan African origin. Longitudinal studies are required to understand the clinical significance of these findings. ©2008 American Medical Association. All rights reserved.
Authors & Co-Authors
Sobngwi, Eugène
France, Paris
Hôpital Saint-louis
United Kingdom, Newcastle
University of Newcastle Upon Tyne, Faculty of Medical Sciences
Choukem, Siméon Pierre
France, Paris
Hôpital Saint-louis
Agbalika, Félix
France, Paris
Hôpital Saint-louis
France, Paris
Université Paris Cité
Blondeau, Bertrand
France, Paris
Centre de Recherche Des Cordeliers
Fetita, Lila Sabrina
France, Paris
Hôpital Saint-louis
Lebbé, Céleste
France, Paris
Hôpital Saint-louis
France, Paris
Université Paris Cité
Thiam, Doudou
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Cattan, Pierre
France, Paris
Hôpital Saint-louis
France, Paris
Université Paris Cité
Larghéro, Jérôme
France, Paris
Hôpital Saint-louis
France, Paris
Institut de Recherche Saint-louis
France, Paris
Université Paris Cité
Foufelle, Fabienne
France, Paris
Centre de Recherche Des Cordeliers
Ferré, Pascal R.
France, Paris
Centre de Recherche Des Cordeliers
Vexiau, Patrick
France, Paris
Hôpital Saint-louis
France, Paris
Université Paris Cité
Calvo, Fabien
France, Paris
Hôpital Saint-louis
France, Paris
Institut de Recherche Saint-louis
France, Paris
Université Paris Cité
Gautier, Jean François
France, Paris
Hôpital Saint-louis
France, Paris
Université Paris Cité
France, Paris
Centre de Recherche Des Cordeliers
Statistics
Citations: 97
Authors: 14
Affiliations: 6
Identifiers
Doi:
10.1001/jama.299.23.2770
ISSN:
00987484
e-ISSN:
15383598
Research Areas
Genetics And Genomics
Health System And Policy
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study
Case-Control Study
Study Approach
Quantitative