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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
chemistry
Macrophage Hitchhiking Nanoparticles for the Treatment of Myocardial Infarction: An In Vitro and In Vivo Study
Advanced Functional Materials, Volume 33, No. 34, Article 2303658, Year 2023
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Description
Myocardial infarction (MI) is the leading cause of death worldwide. However, current therapies are unable to restore the function of the injured myocardium. Advanced approaches, such as stimulation of cardiomyocyte (CM) proliferation are promising, but suffer from poor pharmacokinetics and possible systemic adverse effects. Nanomedicines can be a solution to the above-mentioned drawbacks. However, targeting the cardiac tissue still represents a challenge. Herein, a MI-selective precision nanosystem is developed, that relies on the heart targeting properties of atrial natriuretic peptide (ANP) and lin-TT1 peptide-mediated hitchhiking on M2-like macrophages. The system based on pH-responsive putrescine-modified acetalated dextran (Putre-AcDEX) nanoparticles, shows biocompatibility with cultured cardiac cells, and ANP receptor-dependent interaction with CMs. Moreover, treatment with nanoparticles (NPs) loaded with two pleiotropic cellular self-renewal promoting compounds, CHIR99021 and SB203580, induces a 4-fold increase in bromodeoxyuridine (BrdU) incorporation in primary cardiomyocytes compared to control. In vivo studies confirm that M2-like macrophages targeting by lin-TT1 peptide enhances the heart targeting of ANP. In addition, NP administration does not alter the immunological profile of blood and spleen, showing the short-term safety of the developed system in vivo. Overall, the study results in the development of a peptide-guided precision nanosystem for delivery of therapeutic compounds to the infarcted heart. © 2023 The Authors. Advanced Functional Materials published by Wiley-VCH GmbH.
Authors & Co-Authors
Nammas, Wail M.
Finland, Turku
Turku Pet Centre
Low, Philip Stewart
United States, West Lafayette
Purdue University
Saraste, Antti
Finland, Turku
Turku Pet Centre
Finland, Turku
Turun Yliopistollinen Keskussairaala
Santos, Hélder A.
Finland, Helsinki
Helsingin Yliopisto
Netherlands, Groningen
Rijksuniversiteit Groningen
Statistics
Citations: 1
Authors: 4
Affiliations: 9
Identifiers
Doi:
10.1002/adfm.202303658
ISSN:
1616301X
Research Areas
Noncommunicable Diseases