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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Insecticide Resistance Alleles Affect Vector Competence of Anopheles gambiae s.s. for Plasmodium falciparum Field Isolates
PLoS ONE, Volume 8, No. 5, Article e63849, Year 2013
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Description
The widespread insecticide resistance raises concerns for vector control implementation and sustainability particularly for the control of the main vector of human malaria, Anopheles gambiae sensu stricto. However, the extent to which insecticide resistance mechanisms interfere with the development of the malignant malaria parasite in its vector and their impact on overall malaria transmission remains unknown. We explore the impact of insecticide resistance on the outcome of Plasmodium falciparum infection in its natural vector using three An. gambiae strains sharing a common genetic background, one susceptible to insecticides and two resistant, one homozygous for the ace-1R mutation and one for the kdr mutation. Experimental infections of the three strains were conducted in parallel with field isolates of P. falciparum from Burkina Faso (West Africa) by direct membrane feeding assays. Both insecticide resistant mutations influence the outcome of malaria infection by increasing the prevalence of infection. In contrast, the kdr resistant allele is associated with reduced parasite burden in infected individuals at the oocyst stage, when compared to the susceptible strain, while the ace-1R resistant allele showing no such association. Thus insecticide resistance, which is particularly problematic for malaria control efforts, impacts vector competence towards P. falciparum and probably parasite transmission through increased sporozoite prevalence in kdr resistant mosquitoes. These results are of great concern for the epidemiology of malaria considering the widespread pyrethroid resistance currently observed in Sub-Saharan Africa and the efforts deployed to control the disease. © 2013 Alout et al.
Authors & Co-Authors
Alout, Haoues
France, Montpellier
Maladies Infectieuses et Vecteurs : Écologie, Génétique, Évolution et Contrôle
Burkina Faso, Ouagadougou
Institut de Recherche en Sciences de la Santé
Tuikue-Ndam, Nicaise
Benin
Institut Des Sciences Biomédicale et Appliquées
France, Marseille
Ird Institut de Recherche Pour le Developpement
Sandeu, Maurice Marcel
France, Marseille
Ird Institut de Recherche Pour le Developpement
Benin, Cotonou
Centre de Recherche Entomologique de Cotonou
Djègbé, Innocent
Benin, Cotonou
Centre de Recherche Entomologique de Cotonou
Chandre, Fabrice
France, Montpellier
Maladies Infectieuses et Vecteurs : Écologie, Génétique, Évolution et Contrôle
Dabiré, Roch Kounbobr
Burkina Faso, Ouagadougou
Institut de Recherche en Sciences de la Santé
Djogbenou, Salako Luc
Benin
Institut Régional de Santé Publique/université D'abomey-calavi
Corbel, Vincent
France, Montpellier
Maladies Infectieuses et Vecteurs : Écologie, Génétique, Évolution et Contrôle
Thailand, Bangkok
Kasetsart University
Cohuet, Anna
France, Montpellier
Maladies Infectieuses et Vecteurs : Écologie, Génétique, Évolution et Contrôle
Burkina Faso, Ouagadougou
Institut de Recherche en Sciences de la Santé
Statistics
Citations: 136
Authors: 9
Affiliations: 7
Identifiers
Doi:
10.1371/journal.pone.0063849
e-ISSN:
19326203
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Multi-countries
Burkina Faso