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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Longitudinal assessment of human immunodeficiency virus type 1 (HIV-1)-specific gamma interferon responses during the first year of life in HIV-1-infected infants
Journal of Virology, Volume 79, No. 13, Year 2005
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Description
Human immunodeficiency virus type 1 (HIV-1) infection results in different patterns of viral replication in pediatric compared to adult populations. The role of early HIV-1-specific responses in viral control has not been well defined, because most studies of HIV-1-infected infants have been retrospective or cross-sectional. We evaluated the association between HIV-1-specific gamma interferon (IFN-γ) release from the cells of infants of 1 to 3 months of age and peak viral loads and mortality in the first year of life among 61 Kenyan HIV-1-infected infants. At 1 month, responses were detected in 7/12 (58%) and 6/21 (29%) of infants infected in utero and peripartum, respectively (P = 0.09), and in ∼50% of infants thereafter. Peaks of HIV-specific spot-forming units (SFU) increased significantly with age in all infants, from 251/106 peripheral blood mononuclear cells (PBMC) at 1 month of age to 501/10 6 PBMC at 12 months of age (P = 0.03), although when limited to infants who survived to 1 year, the increase in peak HIV-specific SFU was no longer significant (P = 0.18). Over the first year of life, infants with IFN-γ responses at 1 month had peak plasma viral loads, rates of decline of viral load, and mortality risk similar to those of infants who lacked responses at 1 month. The strength and breadth of IFN-γ responses at 1 month were not significantly associated with viral containment or mortality. These results suggest that, in contrast to HIV-1-infected adults, in whom strong cytotoxic T lymphocyte responses in primary infection are associated with reductions in viremia, HIV-1-infected neonates generate HIV-1-specific CD8 +-T-cell responses early in life that are not clearly associated with improved clinical outcomes. Copyright © 2005, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Lohman-Payne, Barbara L.
Kenya, Nairobi
University of Nairobi
United States, Seattle
University of Washington
United States, Seattle
Iartp
Slyker, Jennifer A.
United Kingdom, Oxford
Mrc Weatherall Institute of Molecular Medicine
Richardson, Barbra Ann
United States, Seattle
University of Washington
United States, Seattle
Fred Hutchinson Cancer Research Center
Farquhar, Carey
United States, Seattle
University of Washington
Mabuka, Jennifer M.
Kenya, Nairobi
University of Nairobi
Crudder, C.
Kenya, Nairobi
University of Nairobi
Dong, Tao
United Kingdom, Oxford
Mrc Weatherall Institute of Molecular Medicine
Maleche-Obimbo, Elizabeth
Kenya, Nairobi
University of Nairobi
Mbori-Ngacha, Dorothy A.
Kenya, Nairobi
University of Nairobi
Overbaugh, Julie M.
United States, Seattle
Fred Hutchinson Cancer Research Center
Rowland-Jones, Sarah Louise
United Kingdom, Oxford
Mrc Weatherall Institute of Molecular Medicine
John-Stewart, Grace C.
Kenya, Nairobi
University of Nairobi
United States, Seattle
University of Washington
Statistics
Citations: 66
Authors: 12
Affiliations: 5
Identifiers
Doi:
10.1128/JVI.79.13.8121-8130.2005
ISSN:
0022538X
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study