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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Primary exposure to SARS-CoV-2 variants elicits convergent epitope specificities, immunoglobulin V gene usage and public B cell clones
Nature Communications, Volume 13, No. 1, Article 7733, Year 2022
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Description
An important consequence of infection with a SARS-CoV-2 variant is protective humoral immunity against other variants. However, the basis for such cross-protection at the molecular level is incompletely understood. Here, we characterized the repertoire and epitope specificity of antibodies elicited by infection with the Beta, Gamma and WA1 ancestral variants and assessed their cross-reactivity to these and the more recent Delta and Omicron variants. We developed a method to obtain immunoglobulin sequences with concurrent rapid production and functional assessment of monoclonal antibodies from hundreds of single B cells sorted by flow cytometry. Infection with any variant elicited similar cross-binding antibody responses exhibiting a conserved hierarchy of epitope immunodominance. Furthermore, convergent V gene usage and similar public B cell clones were elicited regardless of infecting variant. These convergent responses despite antigenic variation may account for the continued efficacy of vaccines based on a single ancestral variant. © 2022, This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.
Authors & Co-Authors
Lima, Noemia Santana
United States, Bethesda
National Institutes of Health Nih
Wagner, Danielle A.
United States, Bethesda
National Institutes of Health Nih
Henry, Amy R.
United States, Bethesda
National Institutes of Health Nih
Wang, Lingshu
United States, Bethesda
National Institutes of Health Nih
Yang, Eun-sung
United States, Bethesda
National Institutes of Health Nih
O’Dell, Sijy
United States, Bethesda
National Institutes of Health Nih
Schmidt, Stephen D.
United States, Bethesda
National Institutes of Health Nih
Moon, Damee
United States, Bethesda
National Institutes of Health Nih
Chen, Man
United States, Bethesda
National Institutes of Health Nih
Boswell, Kristin L.
United States, Bethesda
National Institutes of Health Nih
Davis, Rachel L.
United States, Bethesda
National Institutes of Health Nih
Narpala, Sandeep R.
United States, Bethesda
National Institutes of Health Nih
O’Connell, Sarah E.
United States, Bethesda
National Institutes of Health Nih
Serebryannyy, Leonid A.
United States, Bethesda
National Institutes of Health Nih
Wang, Jennifer L.
United States, Bethesda
National Institutes of Health Nih
Talana, Chloe Adrienna G.
United States, Bethesda
National Institutes of Health Nih
Leung, Kwanyee
United States, Bethesda
National Institutes of Health Nih
Shi, Wei
United States, Bethesda
National Institutes of Health Nih
Biber, Asaf
Israel, Tel Hashomer Tel Aviv
Chaim Sheba Medical Center Israel
Israel, Tel Aviv-yafo
Tel Aviv University
Rhein, Joshua R.
United States, Minneapolis
University of Minnesota Medical School
Vetter, Sara M.
United States, Saint Paul
Minnesota Department of Health
Novik, Laura
United States, Bethesda
National Institutes of Health Nih
Widge, Alicia Toeruna
United States, Bethesda
National Institutes of Health Nih
Gordon, Ingelise J.
United States, Bethesda
National Institutes of Health Nih
Guech, Mercy
United States, Bethesda
National Institutes of Health Nih
Teng, I. Ting
United States, Bethesda
National Institutes of Health Nih
Phung, Emily
United States, Bethesda
National Institutes of Health Nih
Ruckwardt, Tracy J.
United States, Bethesda
National Institutes of Health Nih
Pegu, Amarendra
United States, Bethesda
National Institutes of Health Nih
Misasi, John N.
United States, Bethesda
National Institutes of Health Nih
Doria-Rose, Nicole A.
United States, Bethesda
National Institutes of Health Nih
Gaudinski, Martin R.
United States, Bethesda
National Institutes of Health Nih
Koup, Richard A.
United States, Bethesda
National Institutes of Health Nih
Kwong, Peter D.
United States, Bethesda
National Institutes of Health Nih
McDermott, Adrian B.
United States, Bethesda
National Institutes of Health Nih
Schacker, Timothy W.
United States, Minneapolis
University of Minnesota Medical School
Levy, Itzchak
Israel, Tel Hashomer Tel Aviv
Chaim Sheba Medical Center Israel
Israel, Tel Aviv-yafo
Tel Aviv University
Mascola, John R.
United States, Bethesda
National Institutes of Health Nih
Sullivan, Nancy J.
United States, Bethesda
National Institutes of Health Nih
Schramm, Chaim A.
United States, Bethesda
National Institutes of Health Nih
Douek, Daniel Cesar
United States, Bethesda
National Institutes of Health Nih
Statistics
Citations: 4
Authors: 41
Affiliations: 5
Identifiers
Doi:
10.1038/s41467-022-35456-2
ISSN:
20411723
Research Areas
Genetics And Genomics