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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Epidermal growth factor receptor (EGFR) mutations and expression in squamous cell carcinoma of the esophagus in central Asia
BMC Cancer, Volume 12, Article 602, Year 2012
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Description
Background: Esophageal squamous cell carcinoma (ESCC) shows geographic variations in incidence, with high incidences (>50/105 person-years) in central Asia, including North Eastern Iran (Golestan) and Northern India (Kashmir). In contrast to Western countries, smoking does not appear to be a significant risk factor for ESCC in central Asia. In lung adenocarcinoma, activating mutations in the gene encoding epidermal growth factor receptor (EGFR) are frequent in tumors of never smokers of Asian origin, predicting therapeutic sensitivity to Egfr-targeting drugs.Methods: In this study 152 cases of histologically confirmed ESCC from Iran (Tehran and Golestan Province) and North India (Kashmir Valley) have been analyzed for EGFR mutation by direct sequencing of exons 18-21. Egfr protein expression was evaluated by immunohistochemistry in 34 samples from Tehran and HER2 mutations were analyzed in 54 cases from Kashmir.Results: A total of 14 (9.2%) EGFR variations were detected, including seven variations in exons. Among those, four (2.6%) were already documented in lung cancers, two were reported as polymorphisms and one was a potentially new activating mutation. All but one variation in introns were previously identified as polymorphisms. Over-expression of Egfr was detected in 22/34 (65%) of tested cases whereas no HER2 mutation was found in 54 cases from Kashmir.Conclusion: Overall, EGFR mutations appear to be a rare event in ESCC in high incidence areas of central Asia, although a very small proportion of cases may harbor mutations predicting sensitivity to anti-Egfr drugs. © 2012 Abedi-Ardekani et al.; licensee BioMed Central Ltd.
Authors & Co-Authors
Abedi-Ardekani, Behnoush
France, Lyon
Centre International de Recherche Sur le Cancer
Iran, Tehran
Digestive Diseases Research Center
Iran, Tehran
Social Security Organization
Dar, Nazir Ahmad
France, Lyon
Centre International de Recherche Sur le Cancer
India, Srinagar
University of Kashmir
Mir, Mohammad Muzaffar
India, Srinagar
Sher-i-kashmir Institute of Medical Sciences
Saudi Arabia, Sakakah
Jouf University
Zargar, Showkat A.
India, Srinagar
Sher-i-kashmir Institute of Medical Sciences
Lone, M. Muqbool
India, Srinagar
Sher-i-kashmir Institute of Medical Sciences
Martel-Planche, Ghyslaine
France, Lyon
Centre International de Recherche Sur le Cancer
Villar, Stéphanie
France, Lyon
Centre International de Recherche Sur le Cancer
Mounawar, Mounia
France, Lyon
Centre International de Recherche Sur le Cancer
United Kingdom, London
The Institute of Cancer Research
Saidi, F.
Iran, Tehran
Digestive Diseases Research Center
Malekzadeh, Reza
Iran, Tehran
Digestive Diseases Research Center
Hainaut, Pierre L.
France, Lyon
Centre International de Recherche Sur le Cancer
France, Dardilly
International Prevention Research Institute
Statistics
Citations: 39
Authors: 11
Affiliations: 8
Identifiers
Doi:
10.1186/1471-2407-12-602
e-ISSN:
14712407
Research Areas
Cancer
Genetics And Genomics
Study Design
Cohort Study