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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Hepatitis E virus Infection in Work Horses in Egypt
Infection, Genetics and Evolution, Volume 7, No. 3, Year 2007
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Description
Hepatitis E virus (HEV) is an important cause of hepatitis among young Egyptian adults with high seroprevalence rates seen in both rural areas of the Nile Delta and in suburban Cairo. Because natural antibodies to HEV have been detected in animals and zoonotic transmission is postulated, we surveyed work horses in Cairo for evidence of HEV exposure and viremia. Sera from 200 Cairo work horses were tested by ELISA for the presence of IgG anti-HEV antibody revealed a seropositivity of 13%. Among 100 samples processed for detection of viral genome by means of nested polymerase chain reaction (N-PCR), 4% were positive and indicative of viremia. Viremic animals were less than 1 year old. Relative to PCR-negative horses, PCR-positive animals demonstrated significant elevation of AST (p = 0.03). Phylogenetic analysis of a 253-bp fragment, in the ORF-1,2,3 overlap region of the HEV genome from the viremic animals showed that three of these viral strains to be identical, and closely related (97-100% nucleotide identity) to two human isolates from Egypt, and distant (78-96%) from 16 other HEV isolates from human and animals and shared 99.6% NI with the fourth strain. The consensus sequence of the four strains was origin obtained elsewhere. These data indicated that horses acquire HEV infection and suggest that cross-species transmission may occur. Whether horses play a role in the transmission of HEV needs further investigation. © 2006.
Authors & Co-Authors
Saad, Magdi Darwish
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
Hussein, H. A.
Egypt, Giza
Faculty of Veterinary Medicine
Bashandy, M. M.
Egypt, Cairo
Faculty of Medicine
Kamel, Hamdy H.
Egypt, Beni Suef
Faculty of Veterinary Medicine
Earhart, Kenneth C.
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
Fryauff, David J.
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
Younan, Mary
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
Mohamed, Amira Hassan
Egypt, Cairo
Faculty of Medicine
Statistics
Citations: 97
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1016/j.meegid.2006.07.007
ISSN:
15671348
Research Areas
Infectious Diseases
Study Locations
Egypt