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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Role of complement cascade in abdominal aortic aneurysms
Arteriosclerosis, Thrombosis, and Vascular Biology, Volume 31, No. 7, Year 2011
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Description
Objective-: The goal of this study was to investigate the role of complement cascade genes in the pathobiology of human abdominal aortic aneurysms (AAAs). Methods and Results-: Results of a genome-wide microarray expression profiling revealed 3274 differentially expressed genes between aneurysmal and control aortic tissue. Interestingly, 13 genes in the complement cascade were significantly differentially expressed between AAA and the controls. In silico analysis of the promoters of the 13 complement cascade genes showed enrichment for transcription factor binding sites for signal transducer and activator of transcription (STAT)5A. Chromatin-immunoprecipitation experiments demonstrated binding of transcription factor STAT5A to the promoters of the majority of the complement cascade genes. Immunohistochemical analysis showed strong staining for C2 in AAA tissues. Conclusion-: These results provide strong evidence that the complement cascade plays a role in human AAA. Based on our microarray studies, the pathway is activated in AAA, particularly via the lectin and classical pathways. The overrepresented binding sites of transcription factor STAT5A in the complement cascade gene promoters suggest a role for STAT5A in the coordinated regulation of complement cascade gene expression. © 2011 American Heart Association, Inc.
Authors & Co-Authors
Hinterseher, Irene
United States, Danville
Geisinger Medical Center
Germany, Dresden
Technische Universität Dresden
Erdman, Robert A.
United States, Danville
Geisinger Medical Center
Vrabec, Tamara R.
United States
Geisinger Health System
Elmore, James R.
United States
Geisinger Health System
Franklin, David P.
United States
Geisinger Health System
Gerhard, Glenn S.
United States, Danville
Geisinger Medical Center
Carey, David J.
United States, Danville
Geisinger Medical Center
Tromp, Gerard C.
United States, Danville
Geisinger Medical Center
Kuivaniemi, Helena
United States, Danville
Geisinger Medical Center
Statistics
Citations: 46
Authors: 9
Affiliations: 6
Identifiers
Doi:
10.1161/ATVBAHA.111.227652
ISSN:
15244636
Research Areas
Genetics And Genomics