Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Naturally acquired antibodies specific for plasmodium falciparum reticulocyte-binding protein homologue 5 inhibit parasite growth and predict protection from malaria
Journal of Infectious Diseases, Volume 209, No. 5, Year 2014
Notification
URL copied to clipboard!
Description
Background. Plasmodium falciparum reticulocyte-binding protein homologue 5 (PfRH5) is a blood-stage parasite protein essential for host erythrocyte invasion. PfRH5-specific antibodies raised in animals inhibit parasite growth in vitro, but the relevance of naturally acquired PfRH5-specific antibodies in humans is unclear.Methods. We assessed pre-malaria season PfRH5-specific immunoglobulin G (IgG) levels in 357 Malian children and adults who were uninfected with Plasmodium. Subsequent P. falciparum infections were detected by polymerase chain reaction every 2 weeks and malaria episodes by weekly physical examination and self-referral for 7 months. The primary outcome was time between the first P. falciparum infection and the first febrile malaria episode. PfRH5-specific IgG was assayed for parasite growth-inhibitory activity.Results. The presence of PfRH5-specific IgG at enrollment was associated with a longer time between the first blood-stage infection and the first malaria episode (PfRH5-seropositive median: 71 days, PfRH5-seronegative median: 18 days; P =. 001). This association remained significant after adjustment for age and other factors associated with malaria risk/exposure (hazard ratio,. 62; P =. 02). Concentrated PfRH5-specific IgG purified from Malians inhibited P. falciparum growth in vitro.Conclusions. Naturally acquired PfRH5-specific IgG inhibits parasite growth in vitro and predicts protection from malaria. These findings strongly support efforts to develop PfRH5 as an urgently needed blood-stage malaria vaccine. © 2013 Published by Oxford University Press.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3923542/bin/supp_209_5_789__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC3923542/bin/supp_jit553_jit553supp.pdf
Authors & Co-Authors
Tran, Tuan M.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Ongoïba, Aissata
Mali, Bamako
University of Sciences
Coursen, Jill D.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Crosnier, Cécile
United Kingdom, Hinxton
Wellcome Sanger Institute
Diouf, Ababacar
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Huang, Chiungyu
United States, Baltimore
The Sidney Kimmel Comprehensive Cancer Center
Li, Shanping
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Doumbo, Safiatou Niare
Mali, Bamako
University of Sciences
Doumtabé, Didier
Mali, Bamako
University of Sciences
Koné, Younoussou
Mali, Bamako
University of Sciences
Bathily, Aboudramane
Mali, Bamako
University of Sciences
Dia, Seydou
Mali, Bamako
University of Sciences
Niangaly, Moussa
Mali, Bamako
University of Sciences
Dara, Charles
Mali, Bamako
University of Sciences
Sangala, Jules A.
Mali, Bamako
University of Sciences
Miller, Louis H.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Doumbo, Ogobara K.
Mali, Bamako
University of Sciences
Kayentao, Kassoum
Mali, Bamako
University of Sciences
Long, Carole A.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Miura, Kazutoyo
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Wright, Gavin J.
United Kingdom, Hinxton
Wellcome Sanger Institute
Traoré, Boubacar M.
Mali, Bamako
University of Sciences
Crompton, Peter Dobbs
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Statistics
Citations: 111
Authors: 23
Affiliations: 4
Identifiers
Doi:
10.1093/infdis/jit553
ISSN:
00221899
Research Areas
Environmental
Infectious Diseases
Maternal And Child Health