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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Antibodies to epstein-barr virus in nasopharyngeal carcinoma, other head and neck neoplasms, and control groups
Journal of the National Cancer Institute, Volume 44, No. 1, Year 1970
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Description
Sera collected in East Africa, Hong Kong, India, and France from patients with head and neck neoplasms, patients with nonneoplastic disease, and donors in apparently good health were titrated for antibodies to the Epstein-Barr virus (EBV) by the indirect immunofluorescence technique. The results were correlated with the clinical and histological diagnoses which, as a rule, became available only after performance of the tests. Of 235 East African and Chinese patients who were classified as cases of nasopharyngeal carcinoma (NPC), 84% had high anti-EBV titers (^1:160) and the geometric mean level was 1:348. The histopathology, whether described as anaplastic carcinoma or not, poorly or moderately well-differentiated, squamous or epidermoid carcinoma, seemed irrelevant. When the NPC patients from Hong Kong were grouped according to the stage of their disease, the incidence of high anti-EBV titers increased successively from 45% in stage I to ultimately 100% in stage V. The geometric mean titers rose correspondingly from 1:103 in the initial to 1:788 in the final stages. In contrast, patients with neoplasms (mainly carcinomas) arising in sites of the head and neck other than the nasopharnyx revealed a sixfold lower incidence of high titers (13%) and a nearly tenfold lower geometric mean level (1:36). Assortment of these patients as to the sites and types of their neoplasms revealed no significant differences in the distribution of anti-EBV levels among the groups so obtained. The incidence. © Oxford University Press.
Authors & Co-Authors
Henle, Werner
United States, Bethesda
National Institutes of Health Nih
United States, Philadelphia
University of Pennsylvania
Henle, Gertrude E.
United States, Philadelphia
University of Pennsylvania
Ho, Hungchiu
China, Hong Kong
Queen Elizabeth Hospital Hong Kong
Burtin, Pierre
France, Villejuif
Institut de Recherches Scientifiques Sur le Cancer
Cachin, Yves
France, Villejuif
Institut de Cancerologie Gustave Roussy
Clifford, Peter
Kenya, Nairobi
Kenyatta National Hospital
Schryver, AndréDe De
Sweden, Stockholm
Karolinska Institutet
De-Thé, Guy B.
France, Lyon
Centre International de Recherche Sur le Cancer
Diehl, Volker
United States, Philadelphia
University of Pennsylvania
Sweden, Stockholm
Karolinska Institutet
Klein, George O.
Sweden, Stockholm
Karolinska Institutet
Statistics
Citations: 418
Authors: 10
Affiliations: 8
Identifiers
Doi:
10.1093/jnci/44.1.225
ISSN:
00278874
e-ISSN:
14602105
Research Areas
Cancer
Study Design
Cohort Study
Study Locations
Multi-countries