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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Autoantibodies Neutralizing Type I IFNs in the Bronchoalveolar Lavage of at Least 10% of Patients During Life-Threatening COVID-19 Pneumonia
Journal of Clinical Immunology, Volume 43, No. 6, Year 2023
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Description
Autoantibodies (auto-Abs) neutralizing type I interferons (IFNs) are found in the blood of at least 15% of unvaccinated patients with life-threatening COVID-19 pneumonia. We report here the presence of auto-Abs neutralizing type I IFNs in the bronchoalveolar lavage (BAL) of 54 of the 415 unvaccinated patients (13%) with life-threatening COVID-19 pneumonia tested. The 54 individuals with neutralizing auto-Abs in the BAL included 45 (11%) with auto-Abs against IFN-α2, 37 (9%) with auto-Abs against IFN-ω, 54 (13%) with auto-Abs against IFN-α2 and/or ω, and five (1%) with auto-Abs against IFN-β, including three (0.7%) with auto-Abs neutralizing IFN-α2, IFN-ω, and IFN-β, and two (0.5%) with auto-Abs neutralizing IFN-α2 and IFN-β. Auto-Abs against IFN-α2 also neutralize the other 12 subtypes of IFN-α. Paired plasma samples were available for 95 patients. All seven patients with paired samples who had detectable auto-Abs in BAL also had detectable auto-Abs in plasma, and one patient had auto-Abs detectable only in blood. Auto-Abs neutralizing type I IFNs are, therefore, present in the alveolar space of at least 10% of patients with life-threatening COVID-19 pneumonia. These findings suggest that these auto-Abs impair type I IFN immunity in the lower respiratory tract, thereby contributing to hypoxemic COVID-19 pneumonia. © 2023, The Author(s).
Authors & Co-Authors
Philippot, Quentin
France, Paris
L'institut Des Maladies Génétiques Imagine
Fekkar, Arnaud
France, Paris
L'institut Des Maladies Génétiques Imagine
France, Paris
Hôpital Universitaire Pitié Salpêtrière
Gervais, Adrian
France, Paris
L'institut Des Maladies Génétiques Imagine
Le Voyer, Tom
France, Paris
L'institut Des Maladies Génétiques Imagine
Bizien, Lucy
France, Paris
L'institut Des Maladies Génétiques Imagine
de Brabander, Justin
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Duitman, Jan Willem
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Netherlands, Amsterdam
Universiteit Van Amsterdam
Netherlands, Amsterdam
Amsterdam Institute for Infection and Immunity
Rosain, Jérémie
France, Paris
L'institut Des Maladies Génétiques Imagine
Migaud, Mélanie
France, Paris
L'institut Des Maladies Génétiques Imagine
Jeljeli, Mohamed Maxime
France, Paris
Université Paris Cité
France, Paris
Hopital Cochin Ap-hp
Hammadi, Boualem
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Marchal, Astrid
France, Paris
L'institut Des Maladies Génétiques Imagine
Nossent, Esther J.
Unknown Affiliation
Meijboom, Lilian J.
Unknown Affiliation
Hugenholtz, Floor
Unknown Affiliation
Vlaar, Alexander Petrus Johannes
Unknown Affiliation
Wiersinga, Willem Joost
Unknown Affiliation
Lutter, René
Unknown Affiliation
van der Poll, Tom
Unknown Affiliation
Bogaard, H. J.
Unknown Affiliation
Heunks, Leo M.A.
Unknown Affiliation
Tuinman, Pieter Roel
Unknown Affiliation
Bonta, Peter I.
Unknown Affiliation
Abel, Laurent
Unknown Affiliation
Al-Muhsen, Saleh Zaid
Unknown Affiliation
Arias, Andrés Augusto
Unknown Affiliation
Bogunovic, Dusan
Unknown Affiliation
Bolze, Alexandre
Unknown Affiliation
Bousfiha, Ahmed Aziz
Unknown Affiliation
Mansouri, Davood
Unknown Affiliation
Meyts, Isabelle
Unknown Affiliation
Pérez de Diego, Rebeca
Unknown Affiliation
Sancho-Shimizu, Vanessa
Unknown Affiliation
Spaan, András N.
Unknown Affiliation
Tangye, Stuart G.
Unknown Affiliation
Zhang, Shenying
Unknown Affiliation
Su, Helen C.
Unknown Affiliation
Zhang, Qian
France, Paris
L'institut Des Maladies Génétiques Imagine
United States, New York
Rockefeller University
Jouanguy, Emmanuelle
France, Paris
L'institut Des Maladies Génétiques Imagine
United States, New York
Rockefeller University
Borie, Raphaël
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
France, Paris
Inserm
Crestani, Bruno
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
France, Paris
Inserm
Luyt, Charles Édouard
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
France, Paris
Inserm
Adle-Biassette, Homa
France, Paris
Hôpital Lariboisiere Ap-hp
France, Paris
Inserm
Sène, Damien
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
France, Paris
Université Paris Cité
Mégarbané, Bruno
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
France, Paris
Inserm
Cobat, Aurélie
France, Paris
L'institut Des Maladies Génétiques Imagine
United States, New York
Rockefeller University
Bastard, Paul
France, Paris
L'institut Des Maladies Génétiques Imagine
United States, New York
Rockefeller University
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Bos, Lieuwe D.J.
Netherlands, Amsterdam
Universiteit Van Amsterdam
Casanova, Jean Laurent
France, Paris
L'institut Des Maladies Génétiques Imagine
United States, New York
Rockefeller University
France, Paris
Hôpital Necker Enfants Malades
United States, Chevy Chase
Howard Hughes Medical Institute
Puel, Anne
France, Paris
L'institut Des Maladies Génétiques Imagine
United States, New York
Rockefeller University
Statistics
Citations: 1
Authors: 50
Affiliations: 15
Identifiers
Doi:
10.1007/s10875-023-01512-9
ISSN:
02719142
Research Areas
Covid
Health System And Policy