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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Diagnostic accuracy of commercial urinary lipoarabinomannan detection in African tuberculosis suspects and patients
International Journal of Tuberculosis and Lung Disease, Volume 13, No. 10, Year 2009
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Description
OBJECTIVE: To evaluate a commercially available antigen capture enzyme-linked immunosorbent assay (ELISA) based on detecting lipoarabinomannan (LAM) in urine for the diagnosis of tuberculosis (TB). DESIGN: Consenting TB suspects and registering TB patients prospectively recruited from three hospitals were asked for two sputum specimens for microscopy and culture, urine for LAM testing and blood for human immunodeficiency virus (HIV) testing, with radiological and clinical follow-up for 2 months. RESULTS: Of 427 participants, complete data were available from 397 (307 adult and 23 adolescent TB suspects, and 67 registering TB patients). HIV prevalence was 77%. TB was diagnosed in 195 (49%), including 161 culture-positive patients, and confidently excluded in 114 (29%) participants. LAM ELISA sensitivity was 44% (95%CI 36-52) for culture-confirmed TB (52% in smear-positive patients). Specificity was 89% (95%CI 81-94). Sensitivity was significantly higher in HIV-related TB (52%, 95%CI 43-62, P < 0.001) compared to HIV-negative TB (21%, 95%CI 9-37). Sensitivity in smear-negative patients was low (28%, 95%CI 13-43) for combined HIV-positive and -negative patients. CONCLUSION: Our findings confirm greater sensitivity of urine LAM detection for HIV-related TB. However, both sensitivity and specificity were suboptimal, suggesting that this version cannot confirm or exclude TB in either HIV-infected or non-infected patients. © 2009 The Union.
Authors & Co-Authors
Mutetwa, Reggie
Unknown Affiliation
Boehme, Catharina C.
Unknown Affiliation
Dimairo, M.
Unknown Affiliation
Bandason, Tsitsi
Unknown Affiliation
Munyati, Shungu S.
Unknown Affiliation
Mangwanya, Douglas
Unknown Affiliation
Mungofa, Stanley
Unknown Affiliation
Butterworth, Anthony E.
Unknown Affiliation
Mason, Peter R.
Unknown Affiliation
Corbett, Elizabeth L.
Unknown Affiliation
Statistics
Citations: 10
Authors: 10
Affiliations: 7
Identifiers
ISSN:
10273719
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study