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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Impairment of T Cell Function in Parasitic Infections
PLoS Neglected Tropical Diseases, Volume 8, No. 2, Article e2567, Year 2014
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Description
In mammals subverted as hosts by protozoan parasites, the latter and/or the agonists they release are detected and processed by sensors displayed by many distinct immune cell lineages, in a tissue(s)-dependent context. Focusing on the T lymphocyte lineage, we review our present understanding on its transient or durable functional impairment over the course of the developmental program of the intracellular parasites Leishmania spp., Plasmodium spp., Toxoplasma gondii, and Trypanosoma cruzi in their mammalian hosts. Strategies employed by protozoa to down-regulate T lymphocyte function may act at the initial moment of naïve T cell priming, rendering T cells anergic or unresponsive throughout infection, or later, exhausting T cells due to antigen persistence. Furthermore, by exploiting host feedback mechanisms aimed at maintaining immune homeostasis, parasites can enhance T cell apoptosis. We will discuss how infections with prominent intracellular protozoan parasites lead to a general down-regulation of T cell function through T cell anergy and exhaustion, accompanied by apoptosis, and ultimately allowing pathogen persistence. © 2014 Rodrigues et al.
Authors & Co-Authors
Rodrigues, Vasco
France, Paris
Cnrs Centre National de la Recherche Scientifique
Portugal, Porto
Instituto de Biologia Molecular e Celular
Cordeiro-da-Silva, Anabela
Portugal, Porto
Instituto de Biologia Molecular e Celular
Portugal, Porto
Universidade do Porto
Laforge, Mireille
France, Paris
Cnrs Centre National de la Recherche Scientifique
Ouaissi, Ali
Portugal, Porto
Instituto de Biologia Molecular e Celular
Akharid, Khadija
Morocco, Casablanca
Hassan Ii University of Casablanca
Silvestre, R. J.
Portugal, Porto
Instituto de Biologia Molecular e Celular
Estaquier, Jérôme
France, Paris
Cnrs Centre National de la Recherche Scientifique
Canada, Quebec
Centre de Recherche en Infectiologie
Statistics
Citations: 80
Authors: 7
Affiliations: 5
Identifiers
Doi:
10.1371/journal.pntd.0002567
ISSN:
19352727
e-ISSN:
19352735
Research Areas
Cancer