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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
CD8 infiltration is associated with disease control and tobacco exposure in intermediate-risk oropharyngeal cancer
Scientific Reports, Volume 10, No. 1, Article 243, Year 2020
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Description
Oropharyngeal squamous cell carcinoma (OPSCC) incidence is increasing at a nearly epidemic rate, largely driven by the human papillomavirus (HPV). Despite the generally favorable clinical outcomes of patients with HPV driven (HPV+) OPSCC, a significant subset of HPV tumors associated with tobacco exposure have diminished treatment response and worse survival. The tumor immune microenvironment (TIME) has been shown to be a critical driver of treatment response and oncologic outcomes in OPSCC generally and HPV+ OPSCC more specifically. However, the impact of tobacco exposure on the TIME in OPSCC patients remains unclear. We analyzed the relationship between TIME, tobacco exposure and clinical outcomes in OPSCC patients (n = 143) with extensive tobacco exposure (median pack-years = 40). P16 overexpression, a surrogate marker of HPV association, was a strong predictor of relapse-free (RFS) and overall survival (OS) (p < 0.001, p < 0.001 respectively) regardless of tobacco exposure and associated strongly with differential infiltration of the tumor by both CD3 and CD8 lymphocytes measured via immunohistochemistry (p < 001, p < 0.001 respectively). CD3 and CD8 infiltration was a strong predictor of RFS and OS and associated strongly with disease stage (AJCC 8th Edition Staging Manual). Tobacco exposure correlated significantly (p < 0.001) with decreased CD8 infiltration in p16+ OPSCC tumors. Our findings demonstrate that the HPV+ OPSCC clinical outcomes are strongly correlated with the TIME, which is potentially modulated by tobacco exposure. Immunomodulatory strategies targeting this disease in smokers must take into consideration the potential modifying effects of tobacco exposure on treatment effectiveness and clinical outcomes. © 2020, The Author(s).
Authors & Co-Authors
Elhalawani, Hesham M.
United States, Houston
The University of Texas Md Anderson Cancer Center
Castro, Patricia D.
United States, Houston
Baylor College of Medicine
Yu, Justin
United States, Houston
Baylor College of Medicine
Ittmann, Michael M.
United States, Houston
Baylor College of Medicine
Mohamed, Abdallah Sherif Radwan
United States, Houston
The University of Texas Md Anderson Cancer Center
Lai, Stephen Y.
United States, Houston
The University of Texas Md Anderson Cancer Center
Fuller, Clifton David
United States, Houston
The University of Texas Md Anderson Cancer Center
Sandulache, Vlad C.
United States, Houston
Baylor College of Medicine
United States, Houston
Michael E. Debakey va Medical Center
Statistics
Citations: 13
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1038/s41598-019-57111-5
ISSN:
20452322
Research Areas
Cancer
Substance Abuse
Study Design
Cohort Study