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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Antioxidant and anti-atherogenic activities of three Piper species on atherogenic diet fed hamsters
Experimental and Toxicologic Pathology, Volume 64, No. 4, Year 2012
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Description
Atherogenic diet is known to induce high plasma lipid concentration, oxidative stress and early atherosclerosis. Antioxidants have potentials to counter the effect of atherogenic diet.The present research aims at evaluating the antioxidant and anti-atherosclerotic activities of three Piper species (Piper guineense, Piper nigrum and Piper umbellatum) on atherogenic diet fed hamsters.Hamsters divided into 8 groups: normal control, atherosclerotic control and six test groups. The normal animals fed normal rodent chow, the atherosclerotic control animals fed the same rodent chow supplemented with 0.2% cholesterol and 10% coconut oil (high cholesterol diet). The 6 test groups' animals fed same diet as the atherosclerotic control group but with additional supplementation of 2 graded doses (1 and 0.25. mg/kg body weight, o.p.) of plant extracts for 12 weeks.The atherogenic diet induced a collapse of the erythrocyte antioxidant defense system (significant decrease in superoxide dismutase, catalase and glutathione peroxidase activities). Atherogenic diet also induced an increase in plasma total cholesterol, triglyceride, thiobarbituric acid reactive substances (TBARS), oxidation of low density lipoprotein cholesterol (LDL) and accumulation of foam cells in the aorta a hall mark for atherosclerosis. Administration of the Piper species prevented the collapse of the antioxidant system and the increase of plasma parameters maintaining them towards normality. The Piper species also prevented LDL oxidation by increasing the time (lag time) for its oxidation.The results suggest that these Piper species have significant antioxidant and anti-atherogenic effect against atherogenic diet intoxication. © 2010 Elsevier GmbH.
Authors & Co-Authors
Agbor, G. A.
Cameroon, Yaounde
Institute of Medical Research and Medicinal Plants Studies
United States, Scranton
The University of Scranton
Vinson, Joe A.
United States, Scranton
The University of Scranton
Sortino, Julianne
United States, Scranton
The University of Scranton
Johnson, Robert
United States, Scranton
The University of Scranton
Statistics
Citations: 42
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1016/j.etp.2010.10.003
ISSN:
09402993
e-ISSN:
16181433
Study Design
Randomised Control Trial