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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
HIV-1 Clade D Is Associated with Increased Rates of CD4 Decline in a Kenyan Cohort
PLoS ONE, Volume 7, No. 11, Article e49797, Year 2012
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Description
HIV-1 is grouped phylogenetically into clades, which may impact rates of HIV-1 disease progression. Clade D infection in particular has been shown to be more pathogenic. Here we confirm in a Nairobi-based prospective female sex worker cohort (1985-2004) that Clade D (n = 54) is associated with a more rapid CD4 decline than clade A1 (n = 150, 20.6% vs 13.4% decline per year, 1.53-fold increase, p = 0.015). This was independent of "protective" HLA and country of origin (p = 0.053), which in turn were also independent predictors of the rate of CD4 decline (p = 0.026 and 0.005, respectively). These data confirm that clade D is more pathogenic than clade A1. The precise reason for this difference is currently unclear, and requires further study. This is first study to demonstrate difference in HIV-1 disease progression between clades while controlling for protective HLA alleles. © 2012 McKinnon et al.
Authors & Co-Authors
McKinnon, Lyle R.
Canada, Toronto
University of Toronto
Kenya, Nairobi
University of Nairobi
Nagelkerke, Nico J.D.
Canada, Winnipeg
University of Manitoba
Netherlands, Rotterdam
Erasmus Mc
United Arab Emirates, Al Ain
United Arab Emirates University
Kaul, Rupert
Canada, Toronto
University of Toronto
Kenya, Nairobi
University of Nairobi
Shaw, Souradet Y.
Canada, Winnipeg
University of Manitoba
Capiña, Rupert
Canada, Winnipeg
National Microbiology Laboratory
Luo, Ma
Canada, Winnipeg
University of Manitoba
Canada, Winnipeg
National Microbiology Laboratory
Kariri, Anthony
Kenya, Nairobi
University of Nairobi
Apidi, Winnie
Canada, Winnipeg
University of Manitoba
Kimani, Makobu
Kenya, Nairobi
University of Nairobi
Wachihi, Charles
Kenya, Nairobi
University of Nairobi
Jaoko, Walter G.
Kenya, Nairobi
University of Nairobi
Kenya, Nairobi
Kenyan Aids Vaccine Initiative
Anzala, Aggrey Omu
Kenya, Nairobi
University of Nairobi
Kenya, Nairobi
Kenyan Aids Vaccine Initiative
Kimani, Joshua
Kenya, Nairobi
University of Nairobi
Canada, Winnipeg
University of Manitoba
Ball, Terry Blake
Kenya, Nairobi
University of Nairobi
Canada, Winnipeg
University of Manitoba
Canada, Ottawa
Public Health Agency of Canada
Plummer, Francis Allan
Kenya, Nairobi
University of Nairobi
Canada, Winnipeg
University of Manitoba
Canada, Winnipeg
National Microbiology Laboratory
Statistics
Citations: 15
Authors: 15
Affiliations: 8
Identifiers
Doi:
10.1371/journal.pone.0049797
e-ISSN:
19326203
Research Areas
Infectious Diseases
Study Design
Cohort Study
Participants Gender
Female