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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Genetic polymorphisms of β
2
- and β
3
-adrenergic receptor genes associated with characteristics of the metabolic syndrome in black South African women
Experimental and Clinical Endocrinology and Diabetes, Volume 116, No. 4, Year 2008
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Description
Background: Genetic variation in the β2 (ADRB2) and β3 (ADRB3) adrenergic receptor genes are associated with obesity and insulin resistance. To further elucidate the role of these genes in the pathophysiology of obesity the present study investigated associations between certain polymorphisms in ADRB2 and ADRB3 and parameters of carbohydrate and lipid metabolism in a population of African origin. Material and Methods: Data of 102 black South African women obtained in the POWIRS (Profile of Obese Women with the Insulin Resistance Syndrome) study were used. Endpoint measurements included several anthropometric variables, resting blood pressure, plasma glucose, insulin, free fatty acids (FFA), ghrelin, leptin and lipids, and insulin resistance as estimated by the homeostasis model assessment (HOMA-IR) index. Polymorphisms were analyzed via PCR based methods. Results: The percentage body fat was significantly lower (p≤0.05) and the FFA significantly higher (p≤0.05) in lean subjects (BMI≤25 kg/m2) with the Glu27 variant allele compared to subjects with the Gln27 wildtype allele of the ADRB2 gene. In contrast, the variant allele of the ADRB2 gene was significantly positive associated (p≤0.05) with the HOMA-IR-index in overweight black African women (BMI>25 kg/m2). No significant differences in parameters of the metabolic syndrome were apparent between subjects with the wildtype and variant alleles in the ADRB3 gene. Conclusion: The presence of the Glu27 and Arg64 polymorphisms of the ADRB2 and ADRB3 genes are not directly related to indices of the metabolic syndrome. © J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart.
Authors & Co-Authors
Van Rooyen, Johannes Marthinus
South Africa, Potchefstroom
North-west University
Pretorius, Piet J.
South Africa, Potchefstroom
North-west University
Britz, M.
South Africa, Potchefstroom
North-west University
Huisman, Hugo Willem
South Africa, Potchefstroom
North-west University
Schutte, Aletta E.
South Africa, Potchefstroom
North-west University
Towers, Gordon Wayne
South Africa, Potchefstroom
North-west University
Olckers, Antonel
South Africa, Potchefstroom
North-west University
South Africa, Pretoria
Dnabiotec Pty Ltd
Schwarz, Peter Ee H.
Germany, Dresden
Universitätsklinikum Carl Gustav Carus Dresden
Germany, Dresden
Medizinische Fakultät Carl Gustav Carus
Malan, Nicolaas Theodor
South Africa, Potchefstroom
North-west University
Malan, Leoné
South Africa, Potchefstroom
North-west University
Schutte, Rudolph
South Africa, Potchefstroom
North-west University
Statistics
Citations: 11
Authors: 11
Affiliations: 4
Identifiers
Doi:
10.1055/s-2007-992785
ISSN:
09477349
Research Areas
Genetics And Genomics
Noncommunicable Diseases
Study Design
Cross Sectional Study
Participants Gender
Female