Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
A study of cortical morphology in children with fetal alcohol spectrum disorders
Human Brain Mapping, Volume 35, No. 5, Year 2014
Notification
URL copied to clipboard!
Description
Prenatal alcohol exposure is responsible for a broad range of brain structural malformations, which can be studied using magnetic resonance imaging (MRI). Advanced MRI methods have emerged to characterize brain abnormalities, but the teratogenic effects of alcohol on cortical morphology have received little attention to date. Twenty-four 9-year-old children with fetal alcohol spectrum disorders (9 with fetal alcohol syndrome, 15 heavy exposed nonsyndromal children) and 16 age-matched controls were studied to assess the effect of alcohol consumption during pregnancy on cortical morphology. An automated method was applied to 3D T1-weighted images to assess cortical gyrification using global and regional sulcal indices and two region-based morphological measurements, mean sulcal depth and fold opening. Increasing levels of alcohol exposure were related to reduced cortical folding complexity, even among children with normal brain size, indicating a reduction of buried cortical surface. Fold opening was the strongest anatomical correlate of prenatal alcohol intake, indicating a widening of sulci in all regions that were examined. These data identify cortical morphology as a suitable marker for further investigation of brain damage associated with prenatal alcohol exposure. © 2013 Wiley Periodicals, Inc.
Authors & Co-Authors
De Guio, François
France, Gif-sur-yvette
Commissariat a L'energie Atomique et Aux Energies Alternatives
Mangin, Jean François
France, Gif-sur-yvette
Commissariat a L'energie Atomique et Aux Energies Alternatives
Rivière, Denis
France, Gif-sur-yvette
Commissariat a L'energie Atomique et Aux Energies Alternatives
Perrot, Matthieu
France, Gif-sur-yvette
Commissariat a L'energie Atomique et Aux Energies Alternatives
Molteno, Christopher D.
South Africa, Cape Town
Faculty of Health Sciences
Jacobson, Sandra W.
South Africa, Cape Town
Faculty of Health Sciences
United States, Detroit
Wayne State University School of Medicine
Meintjes, Ernesta M.
South Africa, Cape Town
Faculty of Health Sciences
Jacobson, Joseph L.
South Africa, Cape Town
Faculty of Health Sciences
United States, Detroit
Wayne State University School of Medicine
Statistics
Citations: 60
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1002/hbm.22327
ISSN:
10659471
e-ISSN:
10970193
Research Areas
Maternal And Child Health
Sexual And Reproductive Health
Substance Abuse