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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
chemistry
Synthesis of 4H-chromene, coumarin, 12H-chromeno[2,3-d]pyrimidine derivatives and some of their antimicrobial and cytotoxicity activities
European Journal of Medicinal Chemistry, Volume 46, No. 2, Year 2011
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Description
Condensation of 3-N,N-diethylaminophenol (1) with α- cyanocinnamonitriles (2a-c) and ethyl α-cyanocinnamates (2d-f) provided compounds 3a-f and 4a-c. 12H-Chromeno[2,3-d]pyrimidine derivatives 6, 11-13 and 16 were obtained by treatment of 4H-chromene compounds (3) with different electrophiles followed by nucleophilic reagents. Structures of these compounds were established on the basis of IR, UV, 1H NMR, 13C NMR and MS data. Some of the new compounds were evaluated for antimicrobial and cytotoxicity activities. © 2010 Elsevier Masson SAS. All rights reserved.
Authors & Co-Authors
Sabry, Nermien M.
Saudi Arabia, Abha
King Khalid University
Mohamed, Hany Mostafa
Saudi Arabia, Jazan
Jazan University
Khattab, Essam Shawky A.E.H.
Saudi Arabia, Abha
King Khalid University
Motlaq, Shymaa S.
Saudi Arabia, Abha
King Khalid University
El-Agrody, Ahmed Mohamed
Saudi Arabia, Abha
King Khalid University
Statistics
Citations: 184
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1016/j.ejmech.2010.12.015
ISSN:
02235234
e-ISSN:
17683254