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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Data from complete mtDNA sequencing of Tunisian centenarians: Testing haplogroup association and the "golden mean" to longevity
Mechanisms of Ageing and Development, Volume 130, No. 4, Year 2009
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Description
Since the mitochondrial theory of ageing was proposed, mitochondrial DNA (mtDNA) diversity has been largely studied in old people, however complete genomes are still rare, being limited to Japanese and UK/US samples. In this work, we evaluated possible longevity associated polymorphisms/haplogroups in an African population, from Tunisia, by performing complete mtDNA sequencing. This population has a mixed Eurasian/sub-Saharan mtDNA gene pool, which could potentially facilitate the evaluation of association for sub-Saharan lineages. Sub-Saharan haplogroups were shown to be significantly less represented in centenarians (9.5%) than in controls (54.5%), but it is not possible to rule out an influence of population structure, which is high in these populations. No recurrent polymorphism were more frequent in centenarians than in controls, and although the Tunisian centenarians presented less synonymous and replacement polymorphisms than controls, this difference was not statistically significant. So far, it does not seem that centenarians have significantly less mildly deleterious substitutions, not only in Tunisia but also in Japanese and UK/US samples, as tested here, not favouring a "golden mean" to longevity. © 2008 Elsevier Ireland Ltd. All rights reserved.
Authors & Co-Authors
Costa, Marta Daniela
Portugal, Porto
Universidade do Porto
Cherni, L.
Tunisia, Tunis
Université de Tunis el Manar, Faculté Des Sciences de Tunis
Fernandes, Verónica
Portugal, Porto
Universidade do Porto
Freitas, Fernando
Portugal, Porto
Universidade do Porto
El Gaaied, Amel Ben Ammar
Tunisia, Tunis
Université de Tunis el Manar, Faculté Des Sciences de Tunis
Pereira, Luísa
Portugal, Porto
Universidade do Porto
Portugal, Porto
Faculdade de Medicina da Universidade do Porto Fmup
Statistics
Citations: 37
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1016/j.mad.2008.12.001
ISSN:
00476374
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study
Study Locations
Tunisia