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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Flexibility of Oral Cholera Vaccine Dosing—A Randomized Controlled Trial Measuring Immune Responses Following Alternative Vaccination Schedules in a Cholera Hyper-Endemic Zone
PLoS Neglected Tropical Diseases, Volume 9, No. 3, Year 2015
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Description
Background: A bivalent killed whole cell oral cholera vaccine has been found to be safe and efficacious for five years in the cholera endemic setting of Kolkata, India, when given in a two dose schedule, two weeks apart. A randomized controlled trial revealed that the immune response was not significantly increased following the second dose compared to that after the first dose. We aimed to evaluate the impact of an extended four week dosing schedule on vibriocidal response. Methodology/Principal Findings: In this double blind randomized controlled non-inferiority trial, 356 Indian, non-pregnant residents aged 1 year or older were randomized to receive two doses of oral cholera vaccine at 14 and 28 day intervals. We compared vibriocidal immune responses between these schedules. Among adults, no significant differences were noted when comparing the rates of seroconversion for V. cholerae O1 Inaba following two dose regimens administered at a 14 day interval (55%) vs the 28 day interval (58%). Similarly, no differences in seroconversion were demonstrated in children comparing the 14 (80%) and 28 day intervals (77%). Following 14 and 28 day dosing intervals, vibriocidal response rates against V. cholerae O1 Ogawa were 45% and 49% in adults and 73% and 72% in children respectively. Responses were lower for V. cholerae O139, but similar between dosing schedules for adults (20%, 20%) and children (28%, 20%). Conclusions/Significance: Comparable immune responses and safety profiles between the two dosing schedules support the option for increased flexibility of current OCV dosing. Further operational research using a longer dosing regimen will provide answers to improve implementation and delivery of cholera vaccination in endemic and epidemic outbreak scenarios. © 2015 Kanungo et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC4357440/bin/pntd.0003574.s001.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC4357440/bin/pntd.0003574.s002.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC4357440/bin/pntd.0003574.s003.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC4357440/bin/pntd.0003574.s004.docx
Authors & Co-Authors
Kanungo, Suman
India, Kolkata
National Institute of Cholera and Enteric Diseases India
Desai, Sachin N.
South Korea, Seoul
International Vaccine Institute, Seoul
Nandy, Ranjan Kumar
India, Kolkata
National Institute of Cholera and Enteric Diseases India
Kim, Deokryun
South Korea, Seoul
International Vaccine Institute, Seoul
Sinha, Anuradha K.
India, Kolkata
National Institute of Cholera and Enteric Diseases India
Mahapatra, Tanmay
India, Kolkata
National Institute of Cholera and Enteric Diseases India
Yang, Jae-seung
South Korea, Seoul
International Vaccine Institute, Seoul
Lopez, Anna Lena
Philippines, Manila
National Institutes of Health, University of the Philippines Manila
Manna, Byomkesh
India, Kolkata
National Institute of Cholera and Enteric Diseases India
Ali, Mohammad M.
South Korea, Seoul
International Vaccine Institute, Seoul
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Clemens, John David
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
United States, Los Angeles
Ucla Fielding School of Public Health
Sur, Deepika
India, Kolkata
National Institute of Cholera and Enteric Diseases India
Wierzba, Thomas F.
South Korea, Seoul
International Vaccine Institute, Seoul
Statistics
Citations: 26
Authors: 13
Affiliations: 7
Identifiers
Doi:
10.1371/journal.pntd.0003574
ISSN:
19352727
Research Areas
Disability
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Approach
Quantitative