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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Extended interhuman transmission of monkeypox in a hospital community in the Republic of the Congo, 2003
American Journal of Tropical Medicine and Hygiene, Volume 73, No. 2, Year 2005
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Description
This report describes the first reported outbreak of human monkeypox in the Republic of Congo. Eleven confirmed and probable monkeypox cases were observed during this outbreak, all were less than 18 years old, and most resided on the grounds of the Government Hospital in Impfondo. Molecular, virologic, and serologic, and diagnostic assays were used to detect evidence of monkeypox (or orthopox) virus infection in individuals with striking dermatologic and other clinical manifestations. The majority of cases in this outbreak experienced significant, symptomatic illnesses; there was one death, possibly involving secondary complications, and one instance of profound sequelae. Up to six sequential transmissions of monkeypox virus from person to person are hypothesized to have occurred, making this the longest uninterrupted chain of human monkeypox fully documented to date. The pattern of sustained human-to-human transmission observed during this outbreak may influence our current perception of the capacity for this zoonotic virus to adapt to humans. Copyright © 2005 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Learned, Lynne A.
United States, Buffalo
University at Buffalo, the State University of new York
Reynolds, Mary G.
United States, Atlanta
Viral and Rickettsial Zoonoses Br.
Wassa Wassa, Demole
Congo
Ministry of Health and Population
Li, Yu
United States, Atlanta
Viral and Rickettsial Zoonoses Br.
Olson, Victoria A.
United States, Atlanta
Viral and Rickettsial Zoonoses Br.
Karem, Kevin L.
United States, Atlanta
Viral and Rickettsial Zoonoses Br.
Stempora, Linda L.
United States, Atlanta
Viral and Rickettsial Zoonoses Br.
Braden, Zachary
United States, Atlanta
Viral and Rickettsial Zoonoses Br.
Kline, Richard
United States, Atlanta
Viral and Rickettsial Zoonoses Br.
Likos, Anna
United States, Atlanta
Viral and Rickettsial Zoonoses Br.
Libama, François
Congo
Ministry of Health and Population
Moudzeo, H.
Congo
Ministry of Health and Population
Bolanda, Jean Daniel
Congo
Ministry of Health and Population
Tarangonia, Paul
Congo
Ministry of Health and Population
Boumandoki, Paul J.C.
Congo
Ministry of Health and Population
Formenty, Pierre Bernard Henri
Switzerland, Geneva
Organisation Mondiale de la Santé
Harvey, Joseph M.
Congo
Pioneer Christian Hospital
Damon, Inger K.
United States, Atlanta
Viral and Rickettsial Zoonoses Br.
Statistics
Citations: 288
Authors: 18
Affiliations: 5
Identifiers
Doi:
10.4269/ajtmh.2005.73.428
ISSN:
00029637
Research Areas
Health System And Policy
Infectious Diseases
Study Locations
Congo