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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Immunogenicity of SARS-CoV-2 vaccines in patients with breast cancer
Therapeutic Advances in Medical Oncology, Volume 14, Year 2022
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Description
Purpose: To explore the immunogenicity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines in patients with breast cancer based on type of anticancer treatment. Methods: Patients with breast cancer had anti-spike antibody concentrations measured ⩾14 days after receiving a full SARS-CoV-2 vaccination series. The primary endpoint was IgA/G/M anti-spike antibody concentration. Multiple regression analysis was used to analyze log10-transformed antibody titer concentrations. Results: Between 29 April and 20 July 2021, 233 patients with breast cancer were enrolled, of whom 212 were eligible for the current analysis. Patients who received mRNA-1273 (Moderna) had the highest antibody concentrations [geometric mean concentration (GMC) in log10: 3.0 U/mL], compared to patients who received BNT162b2 (Pfizer) (GMC: 2.6 U/mL) (multiple regression adjusted p = 0.013) and Ad26.COV2.S (Johnson & Johnson/Janssen) (GMC: 2.6 U/mL) (p = 0.071). Patients receiving cytotoxic therapy had a significantly lower antibody titer GMC (2.5 U/mL) compared to patients on no therapy or endocrine therapy alone (3.0 U/mL) (p = 0.005). Patients on targeted therapies (GMC: 2.7 U/mL) also had a numerically lower GMC compared to patients not receiving therapy/on endocrine therapy alone, although this result was not significant (p = 0.364). Among patients who received an additional dose of vaccine (n = 31), 28 demonstrated an increased antibody response that ranged from 0.2 to >4.4 U/ mL. Conclusion: Most patients with breast cancer generate detectable anti-spike antibodies following SARS-CoV-2 vaccination, though systemic treatments and vaccine type impact level of response. Further studies are needed to better understand the clinical implications of different antibody levels, the effectiveness of additional SARS-CoV-2 vaccine doses, and the risk of breakthrough infections among patients with breast cancer. © The Author(s), 2022.
Authors & Co-Authors
Denault, Elyssa N.
United States, Boston
Massachusetts General Hospital
Nakajima, Erika
United States, Boston
Massachusetts General Hospital
Naranbhai, Vivek
United States, Boston
Massachusetts General Hospital
Mortensen, Lindsey J.
United States, Boston
Massachusetts General Hospital
Barabell, Caroline
United States, Boston
Massachusetts General Hospital
Isakoff, Steven Jay
United States, Boston
Massachusetts General Hospital
Iafrate, Anthony John
United States, Boston
Massachusetts General Hospital
Gainor, Justin F.
United States, Boston
Massachusetts General Hospital
Bardia, Aditya
United States, Boston
Massachusetts General Hospital
Spring, Laura M.
United States, Boston
Massachusetts General Hospital
Statistics
Citations: 2
Authors: 10
Affiliations: 1
Identifiers
Doi:
10.1177/17588359221119370
ISSN:
17588340
Research Areas
Cancer
Covid
Study Approach
Quantitative