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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
New prenylated flavanones from erythrina abyssinica with protein tyrosine phosphatase 1B (PTP1B) inhibitory activity
Planta Medica, Volume 76, No. 7, Year 2010
Notification
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Description
As the insulin and leptin signaling pathway can be regulated by PTP1B, it has been suggested that compounds that reduce PTP1B activity or expression levels can be used for treating type 2 diabetes and obesity. In the course of our screening efforts on new PTP1B inhibitors, six new flavanones (16) with dihydrofuran moiety and two known flavanones (7 and 8) were isolated from the stem bark of Erythrina abyssinica (Leguminosae). Their structures were elucidated on the basis of spectroscopic (including UV, CD, MS, 1D, and 2DNMR) and physicochemical analyses. With the exception of 3 and 5, the compounds inhibited PTP1B activity in an in vitro assay with IC50 values ranging from 15.2±1.2 to 19.6±2.3μM, whereas RK-682 as a positive control displayed an IC50 value of 4.7±0.5μM. © Georg Thieme Verlag KG Stuttgart.
Authors & Co-Authors
Cui, Long
South Korea, Daejeon
Korea Research Institute of Bioscience and Biotechnology
Lee, Hyun-sun
South Korea, Daejeon
Korea Research Institute of Bioscience and Biotechnology
Tantoh Ndinteh, Derek Tantoh
Cameroon, Yaounde
Yaoundé I University
Mbafor, Joseph Tanyi
Cameroon, Yaounde
Yaoundé I University
Kim, Youngho
South Korea, Daejeon
Chungnam National University
Le, Thi Van Thu
South Korea, Gwangju
Chosun University
Nguyen, Phi Hung H.
South Korea, Gwangju
Chosun University
Oh, Won Keun
South Korea, Gwangju
Chosun University
Statistics
Citations: 8
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1055/s-0029-1240682
ISSN:
00320943
e-ISSN:
14390221
Research Areas
Noncommunicable Diseases