Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
α-Fetoprotein glycosylation is abnormal in some hepatocellular carcinomas, including white patients with a normal α-fetoprotein concentration
Cancer Letters, Volume 74, No. 1-2, Year 1993
Notification
URL copied to clipboard!
Description
Lectin-affinity analyses with Lens culinaris agglutinin (LCA) and other lectins have demonstrated that the glycosylation of α-fetoprotein (AFP) secreted by hepatocellular carcinomas (HCC) is frequently altered when the serum AFP concentration is increased. To determine if AFP LCA-binding properties are altered in patients with HCC whose serum AFP concentration is normal, the percentage of LCA-binding AFP in serum from white newborns, white normal adults, white patients with chronic hepatitis and hereditary tyrosinemia and white and black patients with HCC were determined. The serum LCA-binding AFP fraction was low in newborns (1-4%) and normal adults (1-8%). There was a significant increase in LCA-binding AFP in patients with chronic hepatitis (10-24%) and hereditary tyrosinemia (5-35%). The AFP LCA-binding fraction was clearly abnormal (greater than 40%) in three of the white patients with an HCC and a normal serum AFP concentration, and the range of values (10-63%) in these HCC patients was similar to that seen in both white and black patients with HCC accompanied by increased AFP concentrations. © 1993.
Authors & Co-Authors
Ajdukiewicz, Andrew Brian
Gambia, Banjul
Medical Research Council Laboratories Gambia
Kelleher, Philip C.
United States, Burlington
University of Vermont Larner College of Medicine
Krawitt, Edward L.
United States, Burlington
University of Vermont Larner College of Medicine
Walters, Carol J.P.
United States, Burlington
University of Vermont Larner College of Medicine
Mason, Pamela B.
United States, Burlington
University of Vermont Larner College of Medicine
Koff, Raymond S.
United States, Framingham
Metrowest Medical Center
Bélanger, Luc
Canada, Quebec
Chu de Québec-université Laval
Statistics
Citations: 7
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1016/0304-3835(93)90042-8
ISSN:
03043835
Research Areas
Infectious Diseases