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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Intracranial and subcortical volumes in adolescents with early-onset psychosis: A multisite mega-analysis from the ENIGMA consortium
Human Brain Mapping, Volume 43, No. 1, Year 2022
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Description
Early-onset psychosis disorders are serious mental disorders arising before the age of 18 years. Here, we investigate the largest neuroimaging dataset, to date, of patients with early-onset psychosis and healthy controls for differences in intracranial and subcortical brain volumes. The sample included 263 patients with early-onset psychosis (mean age: 16.4 ± 1.4 years, mean illness duration: 1.5 ± 1.4 years, 39.2% female) and 359 healthy controls (mean age: 15.9 ± 1.7 years, 45.4% female) with magnetic resonance imaging data, pooled from 11 clinical cohorts. Patients were diagnosed with early-onset schizophrenia (n = 183), affective psychosis (n = 39), or other psychotic disorders (n = 41). We used linear mixed-effects models to investigate differences in intracranial and subcortical volumes across the patient sample, diagnostic subgroup and antipsychotic medication, relative to controls. We observed significantly lower intracranial (Cohen's d = −0.39) and hippocampal (d = −0.25) volumes, and higher caudate (d = 0.25) and pallidum (d = 0.24) volumes in patients relative to controls. Intracranial volume was lower in both early-onset schizophrenia (d = −0.34) and affective psychosis (d = −0.42), and early-onset schizophrenia showed lower hippocampal (d = −0.24) and higher pallidum (d = 0.29) volumes. Patients who were currently treated with antipsychotic medication (n = 193) had significantly lower intracranial volume (d = −0.42). The findings demonstrate a similar pattern of brain alterations in early-onset psychosis as previously reported in adult psychosis, but with notably low intracranial volume. The low intracranial volume suggests disrupted neurodevelopment in adolescent early-onset psychosis. © 2020 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.
Authors & Co-Authors
Gurholt, Tiril P.
Norway, Oslo
Oslo Universitetssykehus
Norway, Oslo
Universitetet I Oslo
Norway, Oslo
Diakonhjemmet Sykehus
Lonning, Vera
Norway, Oslo
Universitetet I Oslo
Norway, Oslo
Diakonhjemmet Sykehus
Nerland, Stener
Norway, Oslo
Universitetet I Oslo
Norway, Oslo
Diakonhjemmet Sykehus
Jørgensen, Kjetil Nordbø
Norway, Oslo
Universitetet I Oslo
Norway, Oslo
Diakonhjemmet Sykehus
Haukvik, Unn Kristin
Norway, Oslo
Oslo Universitetssykehus
Norway, Oslo
Universitetet I Oslo
Alloza, Clara
Spain, Madrid
Centro de Investigación Biomédica en Red de Salud Mental
Arango, Celso
Spain, Madrid
Centro de Investigación Biomédica en Red de Salud Mental
Spain, Madrid
Universidad Complutense de Madrid
Bearden, Carrie E.
United States, Los Angeles
University of California, Los Angeles
Berk, Michael
Australia, Geelong
Deakin University
Australia, Melbourne
Orygen Youth Health
Dandash, Orwa
Australia, Geelong
Deakin University
Díaz-Caneja, M. C.
Spain, Madrid
Centro de Investigación Biomédica en Red de Salud Mental
Spain, Madrid
Universidad Complutense de Madrid
van Erp, Theo G.M.
United States, Irvine
University of California, Irvine
Frangou, Sophia
United States, New York
Icahn School of Medicine at Mount Sinai
Goldstein, Benjamin I.
Canada, Toronto
Sunnybrook Health Sciences Centre
Canada, Toronto
University of Toronto
Jahanshad, Neda
United States, Los Angeles
University of Southern California
James, Anthony C.
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Oxford Health Nhs Foundation Trust
Janssen, Joost
Spain, Madrid
Centro de Investigación Biomédica en Red de Salud Mental
Spain, Madrid
Universidad Complutense de Madrid
Kempton, Matthew J.
United Kingdom, London
King's College London
Kochunov, Peter V.
United States, Baltimore
Maryland Psychiatric Research Center
Rund, Bjørn Rishovd
Norway, Oslo
Universitetet I Oslo
Norway, Drammen
Vestre Viken Hospital Trust
Tamnes, Christian Krog
Norway, Oslo
Universitetet I Oslo
Norway, Oslo
Diakonhjemmet Sykehus
Thomopoulos, Sophia I.
Canada, Toronto
University of Toronto
Wedervang–Resell, Kirsten
Norway, Oslo
Oslo Universitetssykehus
Andreassen, Ole Andreas
Norway, Oslo
Oslo Universitetssykehus
Norway, Oslo
Universitetet I Oslo
Thompson, Paul M.
Canada, Toronto
University of Toronto
Agartz, Ingrid A.
Norway, Oslo
Universitetet I Oslo
Norway, Oslo
Diakonhjemmet Sykehus
Sweden, Stockholm
Karolinska Institutet
Statistics
Citations: 18
Authors: 26
Affiliations: 24
Identifiers
Doi:
10.1002/hbm.25212
ISSN:
10659471
Research Areas
Health System And Policy
Mental Health
Study Design
Cohort Study
Participants Gender
Female