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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Infection with Helicobacter pylori is associated with protection against tuberculosis
PLoS ONE, Volume 5, No. 1, Article e8804, Year 2010
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Description
Background: Helicobacter pylori, a lifelong and typically asymptomatic infection of the stomach, profoundly alters gastric immune responses, and may benefit the host in protection against other pathogens. We explored the hypothesis that H. pylori contributes to the control of infection with Mycobacterium tuberculosis. Methodology/Principal Findings: We first examined M. tuberculosis-specific IFN-c and H. pylori antibody responses in 339 healthy Northern Californians undergoing routine tuberculin skin testing. Of 97 subjects (29%) meeting criteria for latent tuberculosis (TB) infection (LTBI), 45 (46%) were H. pylori seropositive. Subjects with LTBI who were H. pylori-seropositive had 1.5-fold higher TB antigen-induced IFN-c responses (p = 0.04, ANOVA), and a more Th-1 like cytokine profile in peripheral blood mononuclear cells, compared to those who were H. pylori seronegative. To explore an association between H. pylori infection and clinical outcome of TB exposure, we evaluated H. pylori seroprevalence in baseline samples from two high risk TB case-contact cohorts, and from cynomolgus macaques experimentally challenged with M. tuberculosis. Compared to 513 household contacts who did not progress to active disease during a median 24 months follow-up, 120 prevalent TB cases were significantly less likely to be H. pylori infected (AOR: 0.55, 95% CI 0.0.36-0.83, p = 0.005), though seroprevalence was not significantly different from non-progressors in 37 incident TB cases (AOR: 1.35 [95% CI 0.63-2.9] p = 0.44). Cynomolgus macaques with natural H. pylori infection were significantly less likely to progress to TB 6 to 8 months after M. tuberculosis challenge (RR: 0.31 [95% CI 0.12-0.80], p = 0.04). Conclusions/Significance: H. pylori infection may induce bystander effects that modify the risk of active TB in humans and non-human primates. That immunity to TB may be enhanced by exposure to other microbial agents may have important implications for vaccine development and disease control. © 2010 Perry et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC2808360/bin/pone.0008804.s001.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC2808360/bin/pone.0008804.s002.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC2808360/bin/pone.0008804.s003.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC2808360/bin/pone.0008804.s004.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC2808360/bin/pone.0008804.s005.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC2808360/bin/pone.0008804.s006.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC2808360/bin/pone.0008804.s007.doc
Authors & Co-Authors
Perry, Sharon
United States, Stanford
Stanford University School of Medicine
De-Jong, Bouke Catherine
Gambia, Banjul
Medical Research Council Laboratories Gambia
Solnick, Jay V.
United States, Sacramento
Uc Davis School of Medicine
De La Luz Sanchez, Maria
United States, Stanford
Stanford University School of Medicine
Yang, Shufang
United States, Stanford
Stanford University School of Medicine
Lin, Philana Ling
United States, Pittsburgh
Upmc Children’s Hospital of Pittsburgh
Hansen, Lori M.
United States, Sacramento
Uc Davis School of Medicine
Talat, Najeeha
Pakistan, Karachi
The Aga Khan University
Hill, Philip C.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Hussain, Rabia
Pakistan, Karachi
The Aga Khan University
Adegbola, Richard A.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Flynn, Jo Anne L.
United States, Pittsburgh
University of Pittsburgh School of Medicine
Canfield, Don
United States, Sacramento
Uc Davis School of Medicine
Parsonnet, Julie
United States, Stanford
Stanford University School of Medicine
Statistics
Citations: 155
Authors: 14
Affiliations: 6
Identifiers
Doi:
10.1371/journal.pone.0008804
e-ISSN:
19326203
Research Areas
Infectious Diseases
Study Design
Cohort Study