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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Sibling transmission of vaccine-derived rotavirus (RotaTeq) associated with rotavirus gastroenteritis
Pediatrics, Volume 125, No. 2, Year 2010
Notification
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Description
Although rotavirus vaccines are known to be shed in stools, transmission of vaccine-derived virus to unvaccinated contacts resulting in symptomatic rotavirus gastroenteritis has not been reported to our knowledge. We document here the occurrence of vaccine-derived rotavirus (RotaTeq [Merck and Co, Whitehouse Station, NJ]) transmission from a vaccinated infant to an older, unvaccinated sibling, resulting in symptomatic rotavirus gastroenteritis that required emergency department care. Results of our investigation suggest that reassortment between vaccine component strains of genotypes P7[5]G1 and P1A[8]G6 occurred during replication either in the vaccinated infant or in the older sibling, raising the possibility that this reassortment may have increased the virulence of the vaccine-derived virus. Both children remain healthy 11 months after this event and are without underlying medical conditions. Copyright © 2010 by the American Academy of Pediatrics.
Authors & Co-Authors
Payne, Daniel C.
United States, Atlanta
Centers for Disease Control and Prevention
Edwards, Kathryn M.
United States, Nashville
Vanderbilt University Medical Center
Bowen, Michael D.
United States, Atlanta
Centers for Disease Control and Prevention
Esona, Mathew Dioh
United States, Atlanta
Centers for Disease Control and Prevention
Parashar, Umesh D.
United States, Atlanta
Centers for Disease Control and Prevention
Gentsch, Jon R.
United States, Atlanta
Centers for Disease Control and Prevention
Statistics
Citations: 123
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1542/peds.2009-1901
ISSN:
10984275
Research Areas
Maternal And Child Health