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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Achieving treatment goals of reducing or maintaining body iron burden with deferasirox in patients with β-thalassaemia: Results from the ESCALATOR study
European Journal of Haematology, Volume 87, No. 4, Year 2011
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Description
This analysis evaluated the effects of deferasirox on liver iron concentration in moderate and heavily iron-overloaded patients with β-thalassaemia from the ESCALATOR trial (n=231). Mean liver iron concentrations (LIC) decreased significantly from 21.1±8.2 to 14.2±12.1mg Fe/g dry weight (dw) at 2yr (P<0.001) in patients with LIC ≥7mg Fe/g dw at baseline; patients with LIC <7mg Fe/g dw maintained these levels over the treatment period. The proportion of patients with LIC <7mg Fe/g dw increased from 9.4% at core baseline to 39.3% by the end of year 2. The results showed that deferasirox enabled therapeutic goals to be achieved, by maintaining LIC in patients with LIC <7mg Fe/g dw at a mean dose of 22.4±5.2mg/kg/d and significantly reducing LIC in patients with LIC ≥7mg Fe/g dw at a mean dose of 25.7±4.2mg/kg/d, along with a manageable safety profile. © 2011 John Wiley & Sons A/S.
Authors & Co-Authors
Taher, Ali T.
Lebanon, Beirut
American University of Beirut Medical Center
ElAlfy, Mohsen Saleh
Egypt, Cairo
Ain Shams University
Al-Zir, Kusai Nasser
Syrian Arab Republic, Damascus
National Thalassemia Center
Daar, Shahina F.
Oman, Muscat
Sultan Qaboos University
Al-Jefri, Abdullah Hussain
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Habr, Dany
Switzerland, Basel
Novartis International ag
Kriemler-Krahn, Ulrike
Switzerland, Basel
Novartis International ag
Roubert, Bernard
Switzerland, Basel
Novartis International ag
El-Beshlawy, Amal M.
Egypt, Giza
Cairo University
Statistics
Citations: 15
Authors: 9
Affiliations: 7
Identifiers
Doi:
10.1111/j.1600-0609.2011.01661.x
ISSN:
09024441
e-ISSN:
16000609