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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
A comparative lipidomics platform for chemotaxonomic analysis of mycobacterium tuberculosis
Chemistry and Biology, Volume 18, No. 12, Year 2011
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Description
The lipidic envelope of Mycobacterium tuberculosis promotes virulence in many ways, so we developed a lipidomics platform for a broad survey of cell walls. Here we report two new databases (MycoMass, MycoMap), 30 lipid fine maps, and mass spectrometry datasets that comprise a static lipidome. Further, by rapidly regenerating lipidomic datasets during biological processes, comparative lipidomics provides statistically valid, organism-wide comparisons that broadly assess lipid changes during infection or among clinical strains of mycobacteria. Using stringent data filters, we tracked more than 5,000 molecular features in parallel with few or no false-positive molecular discoveries. The low error rates allowed chemotaxonomic analyses of mycobacteria, which describe the extent of chemical change in each strain and identified particular strain-specific molecules for use as biomarkers. © 2011 Elsevier Ltd. All Rights Reserved.
Authors & Co-Authors
Layre, Emilie
United States, Boston
Harvard Medical School
Desjardins, Danielle M.
United States, Boston
Harvard Medical School
Young, David C.
United States, Boston
Harvard Medical School
Cheng, Tan Yuri
United States, Boston
Harvard Medical School
Shamputa, Isdore Chola
United States, Bethesda
National Institutes of Health Nih
Behar, Samuel M.
United States, Boston
Harvard Medical School
Minnaard, Adriaan J.
Netherlands, Groningen
Rijksuniversiteit Groningen
Murray, Megan B.
United States, Boston
Harvard T.h. Chan School of Public Health
Barry, Clifton Earl
United States, Bethesda
National Institutes of Health Nih
Moody, David Branch
United States, Boston
Harvard Medical School
Statistics
Citations: 167
Authors: 10
Affiliations: 6
Identifiers
Doi:
10.1016/j.chembiol.2011.10.013
ISSN:
10745521
Study Design
Cross Sectional Study
Study Approach
Quantitative