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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Genetic polymorphisms in uridine diphospho-glucuronosyltransferase 1A1 and breast cancer risk in Africans
Breast Cancer Research and Treatment, Volume 110, No. 2, Year 2008
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Description
The UDP-glucuronosylatransferase 1A1 (UGT1A1) gene is involved in the metabolism of estrogen and detoxification of potential carcinogens. The number of TA repeats in the promoter region of UGT1A1 has been linked to breast cancer risk, but results varied by race. We performed a comprehensive assessment of genetic polymorphisms in the UGT1A1 gene, and examined these polymorphisms and TA repeats in relation to breast cancer risk in a case-control study in Nigeria. 512 breast cancer cases and 226 community controls were genotyped for UGT1A1. Compared with high-activity TA repeat genotypes, the odds ratios (OR) for low-activity and moderate-activity genotypes were 0.47 (95% confidence interval CI, 0.26-0.83) and 0.64 (95% CI, 0.39-1.06), respectively, in premenopausal women (P = 0.009 for trend), but no association was observed in postmenopausal women (P = 0.24). The effect of TA repeats was also differentiated by age: the OR was 0.39 (95% CI 0.21-0.71) for low-activity genotypes and 0.58 (95% CI 0.33-1.00) for moderate-activity genotypes in women <45 years old (P = 0.002 for trend), but no association was observed in women ≥45 years old (P = 0.15). Haplotype analysis showed that UGT1A1 haplotypes were highly diverse with blocked structures. We found a specific haplotype in block 2 that was significantly associated with a 2.1-fold elevated risk (95% CI 1.05-4.39; P = 0.04). In contrast with previous studies, we found low-activity TA repeat alleles were protective against breast cancer among premenopausal indigenous Africans, suggesting that the role of UGT1A1 in breast cancer development may vary by population, presumably due to different environmental and genetic modifier effects. © 2007 Springer Science+Business Media, LLC.
Authors & Co-Authors
Huo, Dezheng
United States, Chicago
The University of Chicago
Kim, Hee Jin
South Korea, Suwon
Skku School of Medicine
Adebamowo, Clement
Nigeria, Ibadan
University College Hospital, Ibadan
Ogundiran, Temidayo Olusade
Nigeria, Ibadan
University College Hospital, Ibadan
Akang, Effiong E.U.
Nigeria, Ibadan
University College Hospital, Ibadan
Campbell, Oladapo Babatunde
Nigeria, Ibadan
University College Hospital, Ibadan
Adenipekun, Adeniyi Abidemi
Nigeria, Ibadan
University College Hospital, Ibadan
Niu, Qun
United States, Chicago
The University of Chicago
Sveen, Lise W.
United States, Chicago
The University of Chicago
Fackenthal, James D.
United States, Chicago
The University of Chicago
Fackenthal, Donna Lee
United States, Chicago
The University of Chicago
Das, Soma
United States, Chicago
The University of Chicago
Cox, Nancy Jean
United States, Chicago
The University of Chicago
Di Rienzo, Anna
United States, Chicago
The University of Chicago
Olopade, Olufunmilayo Ibironke
United States, Chicago
The University of Chicago
Statistics
Citations: 34
Authors: 15
Affiliations: 3
Identifiers
Doi:
10.1007/s10549-007-9720-7
ISSN:
01676806
Research Areas
Cancer
Genetics And Genomics
Study Design
Cross Sectional Study
Case-Control Study
Study Locations
Nigeria
Participants Gender
Female