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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Complete molecular genome analyses of equine rotavirus a strains from different continents reveal several novel genotypes and a largely conserved genotype constellation
Journal of General Virology, Volume 93, No. 4, Year 2012
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Description
In this study, the complete genome sequences of seven equine group A rotavirus (RVA) strains (RVA/Horse-tc/GBR/L338/1991/G13P[18], RVA/Horse-wt/IRL/03V04954/2003/G3P[12] and RVA/Horse-wt/IRL/04V2024/2004/G14P[12] from Europe; RVA/Horse-wt/ARG/E30/1993/ G3P[12], RVA/Horse-wt/ARG/E403/2006/G14P[12] and RVA/Horse-wt/ARG/E4040/2008/ G14P[12] from Argentina; and RVA/Horse-wt/ZAF/EqRV-SA1/2006/G14P[12] from South Africa) were determined. Multiple novel genotypes were identified and genotype numbers were assigned by the Rotavirus Classification Working Group: R9 (VP1), C9 (VP2), N9 (NSP2), T12 (NSP3), E14 (NSP4), and H7 and H11 (NSP5). The genotype constellation of L338 was unique: G13-P[18]-I6- R9-C9-M6-A6-N9-T12-E14-H11. The six remaining equine RVA strains showed a largely conserved genotype constellation: G3/G14-P[12]-I2/I6-R2-C2-M3-A10-N2-T3-E2/E12-H7, which is highly divergent from other known non-equine RVA genotype constellations. Phylogenetic analyses revealed that the sequences of these equine RVA strains are related distantly to nonequine RVA strains, and that at least three lineages exist within equine RVA strains. A small number of reassortment events were observed. Interestingly, the three RVA strains from Argentina possessed the E12 genotype, whereas the three RVA strains from Ireland and South Africa possessed the E2 genotype. The unusual E12 genotype has until now only been described in Argentina among RVA strains collected from guanaco, cattle and horses, suggesting geographical isolation of this NSP4 genotype. This conserved genetic configuration of equine RVA strains could be useful for future vaccine development or improvement of currently used equine RVA vaccines. © 2012 SGM.
Authors & Co-Authors
Matthijnssens, Jelle
Belgium, Leuven
Rega Institute for Medical Research
Miño, Samuel
Argentina, Buenos Aires
Instituto Nacional de Tecnología Agropecuaria Buenos Aires
Papp, Hajnalka
Hungary, Budapest
Magyar Tudomanyos Akademia
Potgieter, Christiaan Abraham
South Africa, Onderstepoort
Onderstepoort Veterinary Institute
South Africa, Centurion
Deltamune Pty Ltd
Novo, Luis
Belgium, Leuven
Rega Institute for Medical Research
Heylen, Elisabeth
Belgium, Leuven
Rega Institute for Medical Research
Zeller, Mark
Belgium, Leuven
Rega Institute for Medical Research
Garaicoechea, Lorena
Argentina, Buenos Aires
Instituto Nacional de Tecnología Agropecuaria Buenos Aires
Badaracco, Alejandra
Argentina, Buenos Aires
Instituto Nacional de Tecnología Agropecuaria Buenos Aires
Lengyel, György
Hungary, Budapest
Dr. György Radó Military Medical Centre
Kisfali, Péter
Hungary, Pecs
Pécsi Tudományegyetem
Cullinane, Ann
Ireland, Naas
Irish Equine Centre
Collins, P. J.
Ireland, Bishopstown
Munster Technological University Mtu
Ciarlet, Max
United States, Cambridge
Novartis Vaccines and Diagnostics, Inc.
O'Shea, Helen
Ireland, Bishopstown
Munster Technological University Mtu
Parreño, Viviana Gladys
Argentina, Buenos Aires
Instituto Nacional de Tecnología Agropecuaria Buenos Aires
Bányai, Krisztián
Hungary, Budapest
Magyar Tudomanyos Akademia
Barrandeguy, María
Argentina, Buenos Aires
Instituto Nacional de Tecnología Agropecuaria Buenos Aires
van Ranst, Marc A.
Belgium, Leuven
Rega Institute for Medical Research
Statistics
Citations: 62
Authors: 19
Affiliations: 10
Identifiers
Doi:
10.1099/vir.0.039255-0
ISSN:
00221317
e-ISSN:
14652099
Research Areas
Genetics And Genomics
Study Locations
South Africa