Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Postnatal cytomegalovirus exposure in infants of antiretroviral-treated and untreated HIV-infected mothers
Infectious Diseases in Obstetrics and Gynecology, Volume 2014, Article 989721, Year 2014
Notification
URL copied to clipboard!
Description
HIV-1 and CMV are important pathogens transmitted via breastfeeding. Furthermore, perinatal CMV transmission may impact growth and disease progression in HIV-exposed infants. Although maternal antiretroviral therapy reduces milk HIV-1 RNA load and postnatal transmission, its impact on milk CMV load is unclear. We examined the relationship between milk CMV and HIV-1 load (4-6 weeks postpartum) and the impact of antiretroviral treatment in 69 HIV-infected, lactating Malawian women and assessed the relationship between milk CMV load and postnatal growth in HIV-exposed, breastfed infants through six months of age. Despite an association between milk HIV-1 RNA and CMV DNA load (0.39 log10 rise CMV load per log10 rise HIV-1 RNA load, 95% CI 0.13-0.66), milk CMV load was similar in antiretroviral-treated and untreated women. Higher milk CMV load was associated with lower length-for-age (-0.53, 95% CI: -0.96, -0.10) and weight-for-age (-0.40, 95% CI: -0.67, -0.13) Z-score at six months in exposed, uninfected infants. As the impact of maternal antiretroviral therapy on the magnitude of postnatal CMV exposure may be limited, our findings of an inverse relationship between infant growth and milk CMV load highlight the importance of defining the role of perinatal CMV exposure on growth faltering of HIV-exposed infants. © 2014 Sarah A. Meyer et al.
Authors & Co-Authors
Meyer, Sarah A.
United States, Boston
Boston Children's Hospital
Westreich, Daniel
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Patel, Emily M.
United States, Durham
Duke University School of Medicine
Ehlinger, Elizabeth Peek
United States, Boston
Beth Israel Deaconess Medical Center
Kalilani-Phiri, Linda V.
Malawi, Zomba
University of Malawi
Lovingood, Rachel V.
United States, Durham
Duke University Medical Center
Denny, Thomas N.
United States, Durham
Duke University Medical Center
Swamy, Geeta Krishna
United States, Durham
Duke University School of Medicine
Permar, Sallie Robey
United States, Durham
Duke University Medical Center
Statistics
Citations: 19
Authors: 9
Affiliations: 6
Identifiers
Doi:
10.1155/2014/989721
ISSN:
10647449
e-ISSN:
10980997
Research Areas
Genetics And Genomics
Infectious Diseases
Maternal And Child Health
Participants Gender
Female