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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Multidrug-resistant Gram-negative bacterial colonization in patients, carriage by healthcare workers and contamination of hospital environments in Ghana
Journal of Infection and Public Health, Volume 16, Year 2023
Notification
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Description
Background: Patients already colonized with multidrug-resistant (MDR) Gram-negative bacteria (GNB) on admission to critical care units may be an important source of transmission of these bacteria in hospitals. We sought to determine the prevalence of MDR GNB colonization in patients, staff and the ward environment and to assess the risk factors for colonization of patients in wards. Methods: The study was conducted from April 2021 to July 2021 in a teaching hospital in Ghana. MDR GNB were isolated from rectal, and hand swabs were taken from patients on admission and after 48 h. Swabs from HCW's hands and the ward environment were also taken. Risk factors for colonization with MDR GNB were assessed using univariate and multivariate analysis. Results: MDR GNB rectal colonization rate among patients was 50.62% on admission and 44.44% after 48 h. MDR GNB were isolated from 6 (5.26%) and 24 (11.54%) of HCW's hand swabs and environmental swabs, respectively. Previous hospitalization (p-value = 0.021, OR, 95% CI= 7.170 (1.345–38.214) was significantly associated with colonization by MDR GNB after 48 h of admission. Age (21–30 years) (p-value = 0.022, OR, 95% CI = 0.103 (0.015–0.716) was significantly identified as a protective factor associated with a reduced risk of rectal MDR GNB colonization. Conclusion: The high colonization of MDR GNB in patients, the carriage of MDR GNB on HCW's hands, and the contamination of hospital environments highlights the need for patient screening and stringent infection prevention and control practices to prevent the spread of MDR GNB in hospitals. © 2023 The Authors
Authors & Co-Authors
Asare Yeboah, Esther Eyram
South Africa, Durban
University of Kwazulu-natal
Ghana, Accra
Central University
Agyepong, Nicholas
Ghana, Sunyani
Sunyani Technical University
Mbanga, Joshua
South Africa, Durban
University of Kwazulu-natal
Zimbabwe, Bulawayo
National University of Science and Technology Bulawayo
Amoako, Daniel Gyamfi
South Africa, Durban
University of Kwazulu-natal
Canada, Guelph
University of Guelph
Abia, Akebe Lurther King
South Africa, Durban
University of Kwazulu-natal
South Africa, Westville
Environmental Research Foundation
Owusu-Ofori, Alex K.
Ghana, Kumasi
Kwame Nkrumah University of Science & Technology
Ghana, Kumasi
Komfo Anokye Teaching Hospital
Essack, Sabiha Y.
South Africa, Durban
University of Kwazulu-natal
Statistics
Authors: 7
Affiliations: 8
Identifiers
Doi:
10.1016/j.jiph.2023.10.045
ISSN:
18760341
Research Areas
Health System And Policy
Study Design
Cross Sectional Study
Study Locations
Ghana