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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Chlamydia on children and flies after mass antibiotic treatment for trachoma
American Journal of Tropical Medicine and Hygiene, Volume 76, No. 1, Year 2007
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Description
There are various approaches to control trachoma. These include the elimination of the ocular strains of Chlamydia trachomatis that cause the disease and to decrease the spread of infection by other measures such as fly control. Here, we examined how these two are related (i.e., how treating children with antibiotics affects carriage of Chlamydia by flies). Flies were collected in villages that had received mass oral azithromycin distribution and were compared with flies in untreated villages. Polymerase chain reaction (PCR) was performed to detect chlamydial DNA on the flies. Conjunctival swabs were also taken to assay for chlamydial prevalence in the children. Chlamydia was found on 23% of the flies in the untreated villages but only 0.3% in treated villages. Prevalence of trachoma in children proved to be an excellent predictor of the prevalence on flies (correlation coefficient, 0.89). Thus, treating children with antibiotics may drastically reduce the role of flies as a vector. Copyright © 2007 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Lee, Scott L.A.
United States, San Francisco
University of California, San Francisco
Alemayehu, Wondu
Unknown Affiliation
Melese, Muluken
Unknown Affiliation
Lakew, Takele
Unknown Affiliation
Lee, David Chung
United States, San Francisco
University of California, San Francisco
Yi, Elizabeth H.
United States, San Francisco
University of California, San Francisco
Cevallos, Vicky E.
United States, San Francisco
University of California, San Francisco
Donnellan, Cathy
United States, San Francisco
University of California, San Francisco
Zhou, Zhaoxia
United States, San Francisco
University of California, San Francisco
Chidambaram, Jaya Devi
United States, San Francisco
University of California, San Francisco
Gaynor, Bruce D.
United States, San Francisco
University of California, San Francisco
Whitcher, John P.
United States, San Francisco
University of California, San Francisco
Lietman, Thomas M.
United States, San Francisco
University of California, San Francisco
Statistics
Citations: 15
Authors: 13
Affiliations: 1
Identifiers
Doi:
10.4269/ajtmh.2007.76.129
ISSN:
00029637
Research Areas
Genetics And Genomics
Health System And Policy
Maternal And Child Health
Study Design
Cross Sectional Study