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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
First Attempt To Validate Human IgG Antibody Response to Nterm-34kDa Salivary Peptide as Biomarker for Evaluating Exposure to Aedes aegypti Bites
PLoS Neglected Tropical Diseases, Volume 6, No. 11, Article e1905, Year 2012
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Description
Background: Much effort is being devoted for developing new indicators to evaluate the human exposure to Aedes mosquito bites and the risk of arbovirus transmission. Human antibody (Ab) responses to mosquito salivary components could represent a promising tool for evaluating the human-vector contact. Methodology/Principal findings: To develop a specific biomarker of human exposure to Aedes aegypti bites, we measured IgG Ab response to Ae. aegypti Nterm-34 kDa salivary peptide in exposed children in 7 villages of Southern Benin (West Africa). Results showed that specific IgG response presented high inter-individual heterogeneity between villages. IgG response was associated with rainfall and IgG level increased from dry (low exposure) to rainy (high exposure) seasons. These findings indicate that IgG Ab to Nterm-34 kDa salivary peptide may represent a reliable biomarker to detect variation in human exposure to Ae. aegypti bites. Conclusion/Significance: This preliminary study highlights the potential use of Ab response to this salivary peptide for evaluating human exposure to Ae. aegypti. This biomarker could represent a new promising tool for assessing the risk of arbovirus transmission and for evaluating the efficacy of vector control interventions. © 2012 Elanga Ndille et al.
Authors & Co-Authors
Elanga-Ndille, Emmanuel
France, Marseille
Ird Institut de Recherche Pour le Developpement
Benin
Ministère de la Santé Publique
Doucouré, Souleymane
France, Montpellier
Ird Centre de Montpellier
Damien, Georgia Barikissou
France, Marseille
Ird Institut de Recherche Pour le Developpement
Benin
Ministère de la Santé Publique
Mouchet, François
France, Montpellier
Ird Centre de Montpellier
Drame, Papa Makhtar
France, Montpellier
Ird Centre de Montpellier
Cornélie, Sylvie
France, Marseille
Ird Institut de Recherche Pour le Developpement
Benin
Ministère de la Santé Publique
Noukpo, Herbert
France, Marseille
Ird Institut de Recherche Pour le Developpement
Benin
Ministère de la Santé Publique
Yamadjako, Sandra
France, Marseille
Ird Institut de Recherche Pour le Developpement
Benin
Ministère de la Santé Publique
Djènontin, Armel
France, Marseille
Ird Institut de Recherche Pour le Developpement
Benin
Ministère de la Santé Publique
Moiroux, Nicolas
France, Montpellier
Ird Centre de Montpellier
Missé, Dorothée A.
France, Montpellier
Ird Centre de Montpellier
Akogbéto, Martin Codjo
Benin
Ministère de la Santé Publique
Corbel, Vincent
France, Marseille
Ird Institut de Recherche Pour le Developpement
Benin
Ministère de la Santé Publique
Henry, Marie Claire
France, Marseille
Ird Institut de Recherche Pour le Developpement
Benin
Ministère de la Santé Publique
Chandre, Fabrice
France, Montpellier
Ird Centre de Montpellier
Baldet, Thierry
France, Paris
Cirad
Remoué, Franck J.
France, Marseille
Ird Institut de Recherche Pour le Developpement
Benin
Ministère de la Santé Publique
Statistics
Citations: 41
Authors: 17
Affiliations: 4
Identifiers
Doi:
10.1371/journal.pntd.0001905
ISSN:
19352727
e-ISSN:
19352735
Research Areas
Genetics And Genomics
Maternal And Child Health
Study Locations
Multi-countries
Benin