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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Hepatitis B genotypes: Relation to clinical outcome in patients with chronic hepatitis B in Saudi Arabia
World Journal of Gastroenterology, Volume 12, No. 43, Year 2006
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Description
Aim: To identify the most common hepatitis B virus (HBV) genotype in Saudi Arabia, and correlate the prevailing genotypes with the clinical outcome of patients. Methods: Patients were consecutively recruited from the hepatology clinics of two tertiary care referral centers. Patients were categorized into 4 different groups: group 1, patients with hepatitis B and normal liver enzymes; group 2, patients with hepatitis B and abnormal liver enzymes but without cirrhosis; group 3, patients with hepatitis B and liver cirrhosis; group 4, patients with hepatitis B and hepatocellular carcinoma. All patients had a positive hepatitis B surface antigen (HBsAg). Genotyping of HBV was performed by nested PCR mediated amplification of the target sequence and hybridization with sequence-specific oligonucleotides. Results: Seventy patients were enrolled in this study. They were predominantly male (72.9%) in their mid-forty's (mean age 47 years). Forty-nine (70%) patients were hepatitis B envelope antigen (HBeAg) negative. The majority of patients (64%) acquired HBV through unknown risk factors. Hepatitis B genotyping revealed that 57 patients (81.4%) were genotype D, 1 patient (1.4%) had genotype A, 1 patient (1.4%) had genotype C, and 4 patients (5.7%) had genotype E, while 7 patients (10%) had mixed genotype (4 patients ADG, 1 patient DE, 1 patient DF, and 1 patient ADFG). Based on univariate analysis of genotype D patients, significant predictors of advanced liver disease were age, gender, aspartate transaminase, alanine transaminase, albumin, bilirubin, and alkaline phosphatase (all P < 0.001). In multivariate analysis decreased hemoglobin (r = -0.05; 95% CI: -0.08 to -0.03; P = 0.001) and albumin levels (r = -0.004; 95% CI: -0.007 to -0.001; P = 0.002) were highly significant predictors of advanced liver disease. In patients with HBV genotype D, HBeAg negativity was found to increase across advancing stages of liver disease (P = 0.024). Conclusion: This study highlights that the vast majority of Saudi patients with chronic hepatitis B have genotype D. No correlation could be observed between the different genotypes and epidemiological or clinical factors. The relationship between genotype D and HBeAg status in terms of disease severity needs to be further elucidated in larger longitudinal studies. © 2006 The WJG Press. All rights reserved.
Authors & Co-Authors
Abdo, Ayman Assad
Saudi Arabia, Riyadh
King Saud University
Al-Jarallah, Badr M.
Canada, Montreal
Université Mcgill
Sanai, Faisal M.
Saudi Arabia, Riyadh
Riyadh Military Hospital
Hersi, Ahmad Salah
Saudi Arabia, Riyadh
King Saud University
Al-Swat, Khalid A.
Saudi Arabia, Riyadh
King Saud University
Ali Azzam, Nahla Ali
Saudi Arabia, Riyadh
King Saud University
Al-Dukhayil, Manal
Saudi Arabia, Riyadh
King Saud University
Al-Maarik, Amira
Saudi Arabia, Riyadh
King Saud University
Al-Faleh, Faleh Zaid
Saudi Arabia, Riyadh
King Saud University
Statistics
Citations: 76
Authors: 9
Affiliations: 3
Identifiers
Doi:
10.3748/wjg.v12.i43.7019
ISSN:
10079327
Research Areas
Cancer
Genetics And Genomics
Health System And Policy
Infectious Diseases
Study Design
Cohort Study
Participants Gender
Male