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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Ambisome plus miltefosine for Indian patients with kala-azar
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 105, No. 2, Year 2011
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Description
The combination of one intravenous administration of 5. mg/kg Ambisome and oral administration of miltefosine, 2.5. mg/kg/day for 14 days, was evaluated in 135 Indian patients with kala-azar. The Intent-to-Treat cure rate at 6 months was 124 of the 135 enrolled patients (91.9%: 95% CI = 86-96%), and the per protocol cure rate was 124 of 127 evaluable patients (97.6%: 95% CI = 93-100%). Side effects could be attributed to each drug separately: fevers, rigors and back pain due to Ambisome; gastrointestinal side effects due to miltefosine. This combination is attractive for reasons of efficacy, tolerance, and feasibility of administration, although the gastrointestinal side effects of miltefosine require medical vigilance. Clinical Trials.gov identification number: NCT00371995. © 2010 Royal Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Sundar, Santhanam
India, Varanasi
Banaras Hindu University
Pandey, Krishna Kumar
India, Patna
Rajendra Memorial Research Institute of Medical Sciences
Chakravarty, Jaya
India, Varanasi
Banaras Hindu University
Berman, Jonathan Josh
United States, North Potomac
Fast-track Drugs and Biologics
Ghalib, Hashim Warsama
Switzerland, Geneva
Organisation Mondiale de la Santé
Arana, Byron A.
Switzerland, Geneva
Organisation Mondiale de la Santé
Statistics
Citations: 32
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1016/j.trstmh.2010.10.008
ISSN:
00359203
Research Areas
Health System And Policy