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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Plasmacytoid dendritic cell dynamics and alpha interferon production during simian immunodeficiency virus infection with a nonpathogenic outcome
Journal of Virology, Volume 82, No. 11, Year 2008
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Description
We addressed the role of plasmacytoid dendritic cells (PDC) in protection against AIDS in nonpathogenic simian immunodeficiency virus (SIVagm) infection in African green monkeys (AGMs). PDC were monitored in blood and lymph nodes (LNs) starting from day 1 postinfection. We observed significant declines in blood during acute infection. However, PDC then returned to normal levels, and chronically infected AGMs showed no decrease of PDC in blood. There was a significant increase of PDC in LNs during acute infection. Blood PDC displayed only weak alpha interferon (IFN-α) responses to TLR9 agonist stimulation before infection. However, during acute infection, both blood and LN PDC showed a transiently increased propensity for IFN-α production. Bioactive IFN-α was detected in plasma concomitant with the peak of viremia, though levels were only low to moderate in some animals. Plasma interleukin 6 (IL-6) and IL-12 were not increased. In conclusion, PDC were recruited to the LNs and displayed increased IFN-α production during acute infection. However, increases in IFN-α were transient. Together with the lack of inflammatory cytokine responses, these events might play an important role in the low level of T-cell activation which is associated with protection against AIDS in nonpathogenic SIVagm infection. Copyright © 2008, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Diop, Ousmane Madiagne
Senegal, Dakar
Institut Pasteur de Dakar
Ploquin, Mickaël J.Y.
France, Paris
Institut Pasteur, Paris
United States, Providence
Brown University
Mortara, Lorenzo
France, Paris
Institut Pasteur, Paris
Italy, Varese
Università Degli Studi Dell'insubria
Faye, Abdourahmane
Senegal, Dakar
Institut Pasteur de Dakar
Jacquelin, Béatrice
France, Paris
Institut Pasteur, Paris
Kunkel, Désirée
France, Paris
Institut Pasteur, Paris
Lebon, Pierre
France, Paris
Hopital Saint-vincent-de-paul
Butor, Cécile
France, Paris
Institut Cochin
France, Paris
Inserm
France, Paris
Université Paris Cité
Hosmalin, Anne
France, Paris
Institut Cochin
France, Paris
Inserm
Barré-Sinoussi, Françoise C.
France, Paris
Institut Pasteur, Paris
Müller-Trutwin, Michaela C.
France, Paris
Institut Pasteur, Paris
Statistics
Citations: 121
Authors: 11
Affiliations: 8
Identifiers
Doi:
10.1128/JVI.02433-07
ISSN:
0022538X
Research Areas
Infectious Diseases