Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Effect of atorvastatin on inflammation and modification of vascular risk factors in rheumatoid arthritis
Journal of Rheumatology, Volume 38, No. 2, Year 2011
Notification
URL copied to clipboard!
Description
Objective. To investigate the effect of atorvastatin therapy on inflammation, disease activity, endothelial dysfunction, and arterial stiffness in patients with rheumatoid arthritis (RA). Methods. This study included 30 patients with early RA, randomly divided into 2 groups. Group 1 (n = 15) received methotrexate (MTX; 0.2 mg/kg/week; mean (15.5 ± SD 1.3) plus prednisone (10 mg/day). Group 2 (n = 15) received MTX and prednisone with the same previous doses plus atorvastatin therapy (40 mg/day). Ten healthy individuals of similar age and sex served as controls. Disease activity, lipid profile, serum malondialdehyde (MDA), tumor necrosis factor-α (TNF-α), resistin, adiponectin, and brachial artery flow-mediated dilation (FMD) were measured before and after 6 months of treatment. Results. Atorvastatin combined with MTX therapy significantly reduced serum total cholesterol, low-density lipoprotein cholesterol, and triglycerides, and increased high-density lipoprotein cholesterol (p < 0.001). Disease activity variables, serum MDA, TNF-α, resistin, adiponectin, and FMD were significantly improved by the drug combinations (p < 0.001). Conclusion. Atorvastatin therapy in patients with RA reduced disease activity and conventional and novel vascular risk factors that promote the atheromatous lesion. Therapy was also associated with concomitant improvement in endothelial function. The Journal of Rheumatology Copyright © 2011. All rights reserved.
Authors & Co-Authors
El-Barbary, Amal Mohamad
Egypt, Tanta
Faculty of Medicine
Hussein, Manal Shawky
Egypt, Tanta
Faculty of Medicine
Rageh, Elsayed Mohamad
Egypt, Tanta
Faculty of Medicine
Hamouda, Hala E.
Egypt, Tanta
Faculty of Medicine
Wagih, Ayman A.
Egypt, Tanta
Faculty of Medicine
Ismail, Raghda G.
Egypt, Tanta
Faculty of Medicine
Statistics
Citations: 80
Authors: 6
Affiliations: 1
Identifiers
Doi:
10.3899/jrheum.100582
ISSN:
0315162X
e-ISSN:
14992752
Research Areas
Cancer