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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
Evaluation of the mutagenic and antimutagenic effects of South African plants
Journal of Ethnopharmacology, Volume 106, No. 1, Year 2006
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Description
Dichloromethane and 90% methanol extracts of 42 South African plants were screened for mutagenicity and antimutagenicity using the Salmonella/microsome mutagenicity assay (Ames) against Salmonella typhimurium TA98 and TA100 bacterial strains in the presence and absence of metabolic activator S9. The methanol extracts from whole plants of Helichrysum simillimum, Helichrysum herbaceum and Helichrysum rugulosum indicated mutagenicity. These are the first reported tests on the mutagenicity of Helichrysum species. Six species indicated antimutagenic properties, all in the presence of S9: methanol leaf extract of Bauhinia galpinii, and dichloromethane leaf extracts of Bauhinia galpinii, Clerodendrum myricoides, Datura stramonium, Buddleja saligna, Millettia sutherlandii and Sutherlandia frutescens. © 2005 Elsevier Ireland Ltd. All rights reserved.
Authors & Co-Authors
Reid, K. A.
Belgium, Mol
Vlaamse Instelling Voor Technologisch Onderzoek
South Africa, Durban
University of Kwazulu-natal
Maes, Jef
Belgium, Mol
Vlaamse Instelling Voor Technologisch Onderzoek
Maes, Annemarie
Belgium, Mol
Vlaamse Instelling Voor Technologisch Onderzoek
van Staden, Johannes V.
South Africa, Durban
University of Kwazulu-natal
De Kimpe, Norbert G.
Belgium, Ghent
Universiteit Gent
Mulholland, D. A.
South Africa, Durban
University of Kwazulu-natal
Verschaeve, Luc
Belgium, Mol
Vlaamse Instelling Voor Technologisch Onderzoek
Statistics
Citations: 137
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1016/j.jep.2005.11.030
ISSN:
03788741
Research Areas
Infectious Diseases
Noncommunicable Diseases