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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Prevalence of HCV coinfection in HIV-infected individuals in Nigeria and characterization of HCV genotypes
Journal of Clinical Virology, Volume 31, No. SUPPL. 1, Year 2004
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Description
Coinfection with hepatitis C virus (HCV) in individuals infected with HIV is associated with a higher incidence of liver injury, hepatic decompensation, and decreased survival time than that seen in an HIV-monoinfected population. While prevalence studies on HIV/HCV coinfection have been performed in the U.S. and in some European countries, little is known about coinfection rates in Africa. Retrospectively collected specimens from 146 confirmed HIV-positive individuals in Nigeria who had access to antiretroviral therapy (ART) were tested for HCV RNA, using the VERSANT® HCV RNA qualitative assay (TMA), and, if HCV RNA-positive, for HCV genotype using the VERSANT® HCV genotype assay (LiPA). Twelve out of the 146 individuals tested (8.2%) were HCV positive. Nine of the 12 HCV-positive individuals were infected with HCV genotype 1 (five 1a, three 1b, one non-subtypable) and three were infected with HCV genotype 2 (all non-subtypable). Coinfected individuals were more likely to be male, older, and have lower CD4+ cell counts than HIV-monoinfected individuals, although none of the differences reached statistical significance. The results highlight the potential public health impact of HCV infection in Nigeria, where anti-HCV testing is generally not performed in HIV-infected populations or in most blood transfusion centers. © 2004 Elsevier B.V. All rights reserved.
Authors & Co-Authors
Agwale, Simon M.
Nigeria, Abuja
Gede Aids Infect. Dis. Res. Inst.
United States, Bethesda
National Institutes of Health Nih
Tanimoto, Lorine
United States, Whippany
Bayer Corporation, Usa
Womack, Chad
United States, Bethesda
National Institutes of Health Nih
Odama, Lillian Emiola
Nigeria, Abuja
Gede Aids Infect. Dis. Res. Inst.
Leung, Kimmy
United States, Whippany
Bayer Corporation, Usa
Duey, Dolores
United States, Whippany
Bayer Corporation, Usa
Negedu-Momoh, Ruth
Nigeria, Abuja
Gede Aids Infect. Dis. Res. Inst.
Audu, Israel
Nigeria, Abuja
Gede Aids Infect. Dis. Res. Inst.
Mohammed, Shehu B.
Nigeria, Abuja
Gede Aids Infect. Dis. Res. Inst.
Inyang, Uford S.
Nigeria, Abuja
Gede Aids Infect. Dis. Res. Inst.
Graham, Barney S.
Nigeria, Abuja
Gede Aids Infect. Dis. Res. Inst.
Ziermann, Rainer
United States, Whippany
Bayer Corporation, Usa
Statistics
Citations: 80
Authors: 12
Affiliations: 3
Identifiers
Doi:
10.1016/j.jcv.2004.09.001
ISSN:
13866532
Research Areas
Genetics And Genomics
Health System And Policy
Infectious Diseases
Violence And Injury
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Qualitative
Study Locations
Nigeria
Participants Gender
Male