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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Treatment of chronic rhinosinusitis and its effects on asthma
European Respiratory Journal, Volume 28, No. 1, Year 2006
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Description
The effects of rhinosinusitis treatment upon asthma are disputed. The first randomised prospective study of surgical compared with medical therapy of chronic rhinosinusitis in 90 patients with and without nasal polyps was previously reported. Asthma symptoms, control, forced expiratory volume in one second (FEV1), peak flow, exhaled nitric oxide, medication use and hospitalisation at 6 and 12 months from the start of the study were also monitored. This paper reports these results in 43 of those patients with concomitant asthma. Both medical and surgical treatment of chronic rhinosinusitis were associated with subjective and objective improvements in asthma. Overall asthma control improved significantly following both treatment modalities, but was better maintained after medical therapy, where improvement could also be demonstrated in the subgroup with nasal polyps. Medicine was superior to surgery with respect to a decrease in exhaled nitric oxide and increase in FEV1 in the polyp patients. Two patients noted worsening of asthma post-operatively. Improvement in upper airway symptoms, as assessed using a visual analogue scale, correlated with improvement in asthma symptoms and control. Treatment of chronic rhinosinusitis, medical or surgical, benefits concomitant asthma; that associated with nasal polyposis benefits more from medical therapy. Copyright © ERS Journals Ltd 2006.
Authors & Co-Authors
Ragad, S.
Egypt, Tanta
Tanta University Hospitals
Scadding, Glenis Kathleen
United Kingdom, London
Royal National Throat, Nose and Ear Hospital
Lund, Valerie Joan
United Kingdom, London
Royal National Throat, Nose and Ear Hospital
Saleh, Hehsam A.
United Kingdom, London
Charing Cross Hospital
Statistics
Citations: 149
Authors: 4
Affiliations: 3
Identifiers
Doi:
10.1183/09031936.06.00043305
ISSN:
09031936
Research Areas
Health System And Policy
Study Design
Cohort Study