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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Serum total cholesterol levels and all-cause mortality in a home-dwelling elderly population: A six-year follow-up
Scandinavian Journal of Primary Health Care, Volume 28, No. 2, Year 2010
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Description
Objective. To investigate the association between serum total cholesterol and all-cause mortality in elderly individuals aged ≥ 75 years. Design. A prospective cohort study with a six-year follow-up. Setting and subjects. A random sample (n = 700) of all persons aged ≥ 75 years living in Kuopio, Finland. After exclusion of participants living in institutional care and participants using lipid-modifying agents or missing data on blood pressure and cholesterol levels, the fi nal study population consisted of 490 home-dwelling elderly persons with clinical examination. We used the Cox proportional hazard model and the propensity score (PS) method. Main outcome measure. All-cause mortality. Results. In an age-and sex-adjusted analysis, participants with S-TC ≥ 6mmol/l had the lowest risk of death (hazard ratio, HR = 0.48, 95% CI 0.33-0.70) compared with those with S-TC < 5 mmol/l. HR of death for a 1 mmol increase in S-TC was 0.78. In multivariate analyses, the HR of death for a 1 mmol increase in S-TC was 0.82 and using S-TC < 5 mmol/l as a reference, the HR of death for S-TC ≥ 6 mmol/l was 0.59 (95% CI 0.39-0.89) and for S-TC 5.0-5.9 mmol/l, the HR was 0.62 (95% CI 0.42-0.93). In a PS-adjusted model using S-TC < 5 mmol/l as a reference, the HR of death for S-TC ≥ 6 mmol/l was 0.42 (95% CI 0.28-0.62) and for S-TC 5.0-5.9 mmol/l, the HR was 0.57 (95% CI 0.38-0.84). Conclusions. Participants with low serum total cholesterol seem to have a lower survival rate than participants with an elevated cholesterol level, irrespective of concomitant diseases or health status. © 2010 Informa UK Ltd.
Authors & Co-Authors
Tuikkala, Päivi
Finland, Kuopio
Itä-suomen Yliopisto
Hartikainen, Sirpa A.
Finland, Kuopio
Itä-suomen Yliopisto
Korhonen, Maarit Jaana
Finland, Kuopio
Itä-suomen Yliopisto
Lavikainen, Piia T.
Finland, Kuopio
Itä-suomen Yliopisto
Kettunen, Raimo V.J.
Finland, Lahti
Paijat-hame Central Hospital
Sulkava, Raimo O.
Finland, Kuopio
Itä-suomen Yliopisto
Enlund, Hannes K.
Kuwait, Kuwait City
Kuwait University
Statistics
Citations: 58
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.3109/02813432.2010.487371
ISSN:
02813432
e-ISSN:
15027724
Research Areas
Environmental
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative